Biologically active mosaic proteins

Details Biologically active mosaic proteins Biologically active mosaic proteins

1994-10-07

1996-03-12

Patterson, Jr., Charles L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 2, 514 21, 530394, A61K 3822, C07K 1449

Patent

active

054986001

ABSTRACT:
Dimeric proteins having substantially the same biological activity as PDGF are disclosed. More specifically, the proteins may have two polypeptide chains, one of the chains being a mosaic of amino acid sequences substantially identical to portions of the A- or B-chains of PDGF, the second of the chains being substantially homologous to either the A-chain or the B-chain of PDGF, the proteins being chemotactic or mitogenic for fibroblasts. Alternatively, each of the two polypeptide chains may be a mosaic of amino acid sequences as described above. Therapeutic compositions containing these proteins and methods for enhancing the wound-healing process in warm-blooded animals are also disclosed.

REFERENCES:
patent: 4350687 (1982-09-01), Lipton et al.
patent: 4443546 (1984-04-01), Stemerman et al.
patent: 4479896 (1984-10-01), Antoniades
patent: 4546082 (1985-10-01), Kurjan et al.
patent: 4568640 (1986-02-01), Rubin
patent: 4588585 (1986-05-01), Mark et al.
patent: 4590003 (1986-05-01), Twardzik et al.
patent: 4599311 (1986-07-01), Kawasaki
patent: 4605413 (1986-08-01), Urry et al.
patent: 4645828 (1987-02-01), Twardzik et al.
patent: 4673640 (1987-06-01), Backman
patent: 4849407 (1989-07-01), Murray
patent: 5128321 (1992-07-01), Murray
Antoniades et al (1983) Science 220, 963-965.
Blackburn "Enzyme Structure & Function" Marcel Dekker, Inc., New York, pp. 169-223, (1976).
Poggi et al., "Partial Purification and Characterization of Porcine Platelet-derived Growth Factor (PDGF)," Exp. Cell Res. 150:436-441, 1984.
Stoobant et al., "Purification and Properties of Porcine Platelet-Derived Growth Factor," EMBO J. 12:2963-2967, 1984.
Wang et al., "A v-sis Oncogene Protein Produced in Bacteria Competes for Platelet-Derived Growth Factor Binding to its Receptor," J. Biol. Chem. 259:10645-10648, 1984.
Antoniades, "Platelet-Derived Growth Factor and Malignant Transformation," Biochem. Pharm. 33:2823-2828, 1984.
Deuel and Huang, "Platelet-derived Growth Factor," J. Clin. Invest. 74:669-676, 1984.
Huang et al., "Transforming Protein of Simian Sarcoma Virus Stimulates Autocrine Growth of SSV-Transformed Cells Through PDGF Cell-Surface Receptors," Cell 39:79-87, 1984.
Owen et al., "Simian Sarcoma Virus (SSV) Transformed Cells Secrete a Platelet-Derived Growth Factor (PDGF)-Like Mitogen," Fed. Proc. 43:373, 1984.
Owen et al., "Simian Sarcoma Virus-Transformed Cells Secrete a Mitogen Identical to Platelet-Derived Growth Factor," Science 225:54, 1984.
Robbins et al., "Structural and Immunological Similarities Between Simian Sarcoma Virus Gene Product(s) and Human Platelet-Derived Growth Factor," Nature 305:605-608, 1983.
Josephs et al., "Transforming Potential of Human C-sis Nucleotide Sequences Encoding Platelet Derived Growth Factor," Science 225:636-639, 1984.
Robbins et al., "Close Similarities between the Transforming Gene Product of Simian Sarcoma Virus and Human Platelet-derived Growth Factor," Cancer Cells 1:35-42, 1984.
Deuel et al., "Expression of a Platelet-Derived Growth Factor-Like Protein in Simian Sarcoma Virus Transformed Cells," Science 221:1348-1350 (1983).
Raines et al., "Biologic activity of platelet-derived growth factor-related sequences expressed in yeast," J. Cell. Biochem. Supp. (US) (9A):136 (1985).
Heldin and Westermark, "Platelet-Derived Growth Factor: Mechanism of Action and Relation to Oncogenes," Biol. Cell 50:11A, 1984.
Waterfield et al., "Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus," Nature 304:35-39, 1983.
Clarke et al., "Transformation of NIH 3T3 Cells by a Human C-sis cDNA Clone," Nature 308:464, 1984.
Doolittle et al., "Simian Sarcoma Virus Onc Gene, V-sis, Is Derived From the Gene (or Genes) Encoding a Platelet-Derived Growth Factor," Science 221:275-277, 1983.
Dicker et al., "Similarities Between Fibroblast-Derived Growth Factor and Platelet-Derived Growth Factor," Exp. Cell Res. 135:221-227, 1981.
Dicker et al., "Similarities between fibroblast-derived growth factor and platelet-derived growth factor," Chem. Abstr. 95:201393r, 1981.
Heldin et al., "Platelet-derived growth factor," Biochem. J. 193:907-913, 1981.
Robbins et al., "In Vivo Identification of the Transforming Gene Product of Simian Sarcoma Virus," Science 218:1131-1133, 1982.
Devare et al., "Nucleotide sequence of the simian sarcoma virus genome: Demonstration that its acquired cellular sequences encode the transforming gene product p28.sup.sis," Proc. Natl. Acad. Sci. USA 80:731-735, 1983.
Devare et al., "Expression of the PDGF-Related Transforming Protein of Simian Sarcoma Virus in E. coili," Cell 36:43-49, 1984.
Deuel et al., "Human Platelet-Derived Growth Factor," J. Biol. Chem. 256:8896-8899, 1981.
Johnsson et al., "The C-Sis Gene Encodes a Precursor of the B Chain of Platelet-Derived Growth Factor," EMBO J. 3:921-928, 1984.
Johnsson et al., "The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor," Chem. Abstr. 101:84809k, 1984.
Bourne and Rozengurt, "An 18,000 Molecular Weight Polypeptide Induces Early Events and Stimulates DNA Synthesis in Cultured Cells," Proc. Natl. Acad. Sci. USA 73:4555-4559, 1976.
Waterfield et al., "Relationship between the Transforming Protein of Simian Sarcoma Virus and Human Platelet-derived Growth Factor," Cancer Cells 1:25-33, 1984.
Heldin et al., "Mechanism of action of platelet-derived growth factor and its relation to oncogenes," J. Embryol. Exp. Morphol. 82 Suppl.:41, 1984.
Robson et al., "Predictions of the conformation and antigenic determinants of the v-sis viral oncogene product homologous with human platelet-derived growth factor," Chem. Abstr. 102:164950k, 1985.
Johnsson et al., "Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product," Proc. Natl. Acad. Sci. USA 82:1721-1725, 1985.
Gazit et al., "Expression of the Normal Human sis/PDGF-2 Coding Sequence Induces Cellular Transformation," Cell 39:89-97, 1984.
Johnsson et al., "The Structural Relationship Between Human Platelet-Derived Growth Factor and the Transforming Protein of Simian Sarcoma Virus," J. Cell Biochem. Suppl. 8A:64, 1984.
Nister et al., "A Platelet-Derived Growth Factor Analog Produced by a Human Clonal Glioma Cell Line," Ann. N.Y. Acad. Sci. 397:25-33, 1982.
Rozengurt et al., "Inhibition of Epidermal Growth Factor Binding to Mouse Cultured Cells by Fibroblast-derived Growth Factor," J. Biol. Chem. 257:3680-3686, 1982.
Nister et al., "A glioma-derived analog to platelet-derived growth factor: Demonstration of receptor competing activity and immunological crossreactivity," Proc. Natl. Acad. Sci. USA 81:926-930, 1984.
Antoniades and Hunkapiller, "Human Platelet-Derived Growth Factor (PDGF): Amino-Terminal Amino Acid Sequence," Science 220:963-965, 1983.
Antoniades, "Human Platelet-Derived Growth Factor (PDGF): Purification of PDGF-I and PDGF-II and Separation of Their Reduced Subunits," Proc. Natl. Acad. Sci. USA 78:7314-7317, 1981.
Johnsson et al., "Platelet-Derived Growth Factor: Identification of Constituent Polypeptide Chains," Biochem. Biophys. Res. Comm. 104:66-74, 1982.
Bowen-Pope et al., "Production of Platelet-Derived Growth Factor-Like Molecules and Reduced Expression of Platelet-Derived Growth Factor Receptors Accompany Transformation by a Wide Spectrum of Agents," Proc. Natl. Acad. Sci. USA 81:2396-2400, 1984.
Scher et al., "Transforming Viruses Directly Reduce the Cellular Growth Requirement for a Platelet Derived Growth Factor," J. Cell Physiol. 97:371-380, 1978.
Chesterman et al., "Comparison of Platelet-Derived Growth Factor Prepared From Release Products of Fresh Platelets and From Outdated Platelet Concentrates," Biochem. Biophys. Res. Comm. 116:809-816, 1983.
Westermark et al., "Platelet-Derived Growth Factor," Horm. Cell Reg. 8:9-15, 1984.
Niman, "Antisera to a synthetic peptide of the sis viral oncogene product recognize human platelet-derived growth factor," Nature 307:180-183, 1984.
Josephs et al., "Human Proto-Oncogene Nucleotide Sequences Corresponding to the Transforming Region of Simian Sarcoma Virus," Science 223:487-4

Affiliated with

Also associated with

Rating

Biologically active mosaic proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biologically active mosaic proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biologically active mosaic proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2099984