Biologically active fragments of IL-1.beta.

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

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530344, 530350, 530351, 435 691, 435 695, A61K 3800, C07K 200, C07K 100, C12P 2106

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active

05998578&

ABSTRACT:
The subject invention concerns a nucleic acid comprising a nucleotide sequence encoding human interleukin-1 (IL-1), and fragments thereof, and the polypeptides and peptides obtained. Specifically, the subject invention comprises the cloning of a cDNA synthesized by reverse transcription of poly(A)RNA isolated from adherent human monocytes stimulated with bacterial endotoxin. Human IL-1 is useful to induce the production of IL-2 by activated T-cells; it also acts on B-cells and NK-cells. The subject invention further concerns antibodies that are immunoreactive with human IL-1.beta. proteins.

REFERENCES:
patent: 4772685 (1988-09-01), Schmidt et al.
patent: 4898818 (1990-02-01), Nakai et al.
patent: 4935343 (1990-06-01), Allison et al.
patent: 5510462 (1996-04-01), Auron et al.
patent: 5595915 (1997-01-01), Geysen
Dinarello, C.A. (1984) "Interleukin-1" Reviews of Infectious Diseases 6(1):51-95.
Kampschmidt, R.F. (1981) "Leukocytic endogenous mediator/endogenous pyrogen" Infection: The physiologic and metabolic responses of the host, pp. 56-74.
Kock, A. et al. (1986) "Characterization of a Monoclonal Antibody Directed Against the Biologically Active Site of Human Interleukin 1" J. Exp. Med. 163:463-468.
Mizel, S.B. et al. (1981) "Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1)" Proc. Natl. Acad. Sci. 78(4):2474-2477.
Mizel, S.B. et al. (1983) "Preparation of Goat Antibodies Against Interleukin 1: Use of an Immunoadsorbent to Purify Interleukin 1" The Journal of Immunology 131(4) :1834-1837.
Murphy, P.A. et al. (1980) "Endogenous Pyrogens Made by Rabbit Peritoneal Exudate Cells are Identical with Lymphocyte-Activating Factors Made by Rabbit Alveolar Macrophages" The Joournal of Immunology 124(5):2498-2501.
Okayama, H., P. Berg (1983) "A cDNA Cloning Vector That Permits Expression if cDNA Inserts in Mammalian Cells" Molecular and Celluar Biology 3(2):280-289.
Roberts, T.M. et al. (1979) "A general method for maximizing the expression of a cloned gene" Proc. Natl. Acad. Sci. USA 76(2):760-764.
Rosenwasser, L.J., C.A. Dinarello (1981) "Ability of Human Luekocytic Pyrogen to Enhance Phytohemagglutinin Induced Murine Thymocyte Proliferation" Cellular Immunology 63:134-142.
Rosenwasser, L.J. et al. (1979) "Adherent Cell Function in Murine T-Lymphocyte Antigen Recognition" The Journal of Experimental Medicine 150:709-714.
Stadler, B.M. et al. (1981) "Monoclonal Antibodies Against the Interleukins" Lymphokines and Thymic Hormones: Their Potential Utilization in Cancer Therapeutics, pp. 69-76.
Windle, J.J. et al. (1984) "Induction of Interleukin 1 Messenger RNA and Translation in Oocytes" The Journal of Immunology 132(3):1317-1322.
Wunderlich, D.A. et al. (1988) Generation of Neutralizing Monoclonal Antibodies Specific for Human Interleukin-1 Beta Monokines and Other Lymphocytic Cytokines, pp. 383-385.
Stadler, B.M. et al. (1982) "Monoclonal antibodies against the interleukins" Chemical Abstracts 96:484, abstract No. 33132e.
Lachman, L.B. (1983) "Human interleukin 1: purification and properties" Immunochemistry 99:405, abstract No. 36951u.
Auron, P.E. et al. (1984) "Molecular cloning of human interleukin-1 cDNA" Biological Abstracts vol. 28, abstract No. 54236.
Auron, P.E. et al. (1984) "Nucleotide sequence of human monocyte interleukin 1 precursor cDNA" Proc. Natl. Acad. Sci. USA 81:7907-7911.
Hazuda, D.J. et al. (1990) "Processing of Precursor Interleukin 1.beta. and Inflammatory Disease" The Journal of Biological Chemistry 265(11):6318-6322.
Mosley, B. et al. (1987) "Determination of the minimum polypeptide lengths of the functionally active sites of human interleukins 1.alpha. and 1.beta." Proc. Natl. Acad. Sci. USA 84:4572-4576.
Dinarello et al PNAS 74: 4624-4627 1977.
Sevier et al Clinical Chemistry (27) pp. 11797-11806 1981.
Lazar et al Molecular & Cellular Biology vol. 8(3) pp. 1247-1252 Mar. 1988.
Burgess et al J. of Cell Biology v111 pp. 2129-2138 Nov. 1990.

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