Biologically active fragments of glucagon-like insulinotropic pe

Details Biologically active fragments of glucagon-like insulinotropic pe Biologically active fragments of glucagon-like insulinotropic pe

1994-08-30

1996-11-12

Allen, Marianne P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530308, 530324, 514866, A61K 3800, A61K 3826, C07K 14605

Patent

active

055740081

ABSTRACT:
N-terminal truncated forms of glucagon like insulinotropic peptide (GLP-1) and analogs thereof are provided. The claimed polypeptides promote glucose uptake by cells but do not stimulate insulin expression or secretion. The invention also provides methods for treating diabetes and pharmaceutical formulations comprising the claimed polypeptides.

REFERENCES:
patent: 5118666 (1992-06-01), Habener
patent: 5120712 (1992-06-01), Habener
patent: 5512549 (1996-04-01), Chen et al.
Granott, D. et al., Digestion, 55(5):302, 1994.
Kreymann, et al., "Glucagon-Like Peptide 7-36 A Physiological Incretin In Man", The Lancet, vol. 2, pp. 1300-1303 (Dec. 5, 1987).
Holst, et. al., "Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut", FEBS Letters, vol. 211, No. 2, pp. 169-174 (Jan. 1987).
Mojsov, et. al., "Insulinotropic: Glucagon-like Peptide I (7-37) Co.-encoded in the Glucagon Gene Is a Potent Stimulator of Insulin Release in the Perfused Rat Pancreas", The American Society for Clinical Investigation, Inc., vol. 79, pp. 616-619 (Feb. 1987).
Goke, et. al., "Glucagon like peptide-1 (7-36) amide is a new incretin/enterogastrone candidate", European Journal of Clinical Investigation, vol. 21, pp. 135-144 (1991).
Suzuki, et. al., "Effects Of GLP-1 And Its Fragment Peptides On Pancreatic Hormone Release", Diabetes Research and Clinical Practice, Supp. 1, vol. 5, ORA-007-007, p. S30 (1988).
Weir, et. al., "Glucagonlike Peptide I (7-37) Actions on Endocrine Pancreas", Diabetes, vol. 38, pp. 338-342 (Mar. 1989).
Komatsu, et. al., "Glucagonostatic and Insulinotropic Action of Glucagonlike Peptide I-(7-36)-Amide", Diabetes, vol. 38, pp. 903-905, (Jul. 1989).
Orskov, et. al., "Complete Sequences of Glucagon-like Peptide-1 from Human and Pig Small Intestine", The Journal of Biological Chemistry, vol. 264, No. 22, pp. 12826-12929, (Aug. 5, 1989).
Takahashi, et. al., "Radioimmunoassay For Glucagon-Like Peptide-1 In Human Plasma Using N-Terminal And C-Terminal Directed Antibodies: A Physiologic Insulinotropic Role of GLP-1 (7-36 Amide)", Biomedical Research vol. 11 (2), pp. 99-108, (1990).
Mojsov, "Structural requirements for biological activity of glucagon-like peptide-I", Int J Peptide Protein Res, vol. 40, pp. 333-343 (1992).
Orskov, "Glucagon-like peptide-1, a new hormone of the entero-insular axis", Diabetologia, vol. 35, pp. 701-711 (1992).
Thorens, et. al., "Glucagon-Like Peptide-I and the Control of Insulin Secretion in the Normal State and in NIDDM", Diabetes, vol. 42, pp. 1219-1225 (Sep. 1992).
Nauck, et. al., "Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide in Type 2 (non-insulin-dependent) diabetic patients", Diabetologia, vol. 36, pp. 741-744 (1993).
Nauck, et. al., "Preserved Incretin Activity of Glucagon-like Peptide 1 (7-36 Amide) but Not of Synthetic Human Gastric Inhibitory Polypeptide in Patients with Type-2 Diabetes Mellitus", The American Society for Clinical Investigation, Inc., vol. 91, pp. 301-307, (Jan. 1993).
Hvidberg, et. al., "Effect of Glucagon-like Peptide-1 (proglucagon 78-107 amide) on Hepatic Glucose Production in Healthy Man", Metabolism, vol. 43, No. 1, pp. 104-108, (Jan. 1994).
Suzuki, S., et al. "Comparison of the Effects of Various C-Terminal and N-Terminal Fragment Peptides of Glucagon-Like Peptide-1 on Insulin and Glucagon Release from the Isolated Perfused Rat Pancreas" Endocrinology, vol. 125, No. 6, 3109-3114 (1989).

Affiliated with

Also associated with

Rating

Biologically active fragments of glucagon-like insulinotropic pe does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biologically active fragments of glucagon-like insulinotropic pe, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biologically active fragments of glucagon-like insulinotropic pe will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-562537