Biologically active dimerized and multimerized polypeptide fusio

Details Biologically active dimerized and multimerized polypeptide fusio Biologically active dimerized and multimerized polypeptide fusio

1997-11-26

2000-01-25

Spector, Lorraine

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

5303873, 53038824, 530399, 530402, C07K 1900, C07K 1646, C07K 1471

Patent

active

060180269

ABSTRACT:
Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.

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