Biologically active conjugates and their preparation and use

Details Biologically active conjugates and their preparation and use Biologically active conjugates and their preparation and use

1984-06-14

1987-05-05

Marantz, Sidney

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Stablizing an enzyme by forming a mixture, an adduct or a...

435 22, 435 23, 25217412, 25217423, 252DIG12, 530300, 530350, 530354, C12N 996, C12Q 140, C12Q 138, C11D 1700

Patent

active

046632875

ABSTRACT:
Water-soluble, biologically active conjugates comprising residues of (1) a biologically active protein or glycoprotein having primary amino groups, (2) a heteropolymer of D-mannuronic acid and L-guluronic acid and (3) an alkyleneglycol of 2 to 6 carbon atoms, the said residue (2) being linked to (1) by an amide linkage and to (3) by an ester linkage, which conjugates have increased activity at higher pH values and higher temperatures and a process for their preparations.

REFERENCES:
A. B. Salleh et al., Biotechnology Letters, vol. 4(6), pp. 387-392 (1982).
J. J. Marshall et al., Biotechnology and Bioengineering, vol. XIX, pp. 1739-1760 (1977).
J. J. Marshall et al., Biotechnology and Bioengineering, vol. XVIII, pp. 1325-1329 (1976).
R. McDowell, J. Soc. Cosmet. Chem., vol. 21, pp. 441-457 (1970).

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