Biologically active compounds obtainable from Sorangium...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S217000, C514S375000

Reexamination Certificate

active

07947719

ABSTRACT:
The present invention relates to a novel group of compounds having antibiotic, antifungal and/or cytostatic properties, which are obtainable from myxobacteria, especially of the genusSorangium, preferablySorangium cellulosum. One representative of this group of compounds is currently named Disorazole Z and Disorazole Z-epoxide, respectively, with specific substituents and specific unsaturated bonds to its cyclic core structure:

REFERENCES:
Jin, Zhong, 2006; Natural Product Reports; vol. 23, 464-496.
Wipf et. al., 2006; Chemical and Biological Drug Design; vol. 67; pp. 66-73.
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.
Jansen, et. al.; Liebigs Annalen der Chemie (1994), (8), 759-73.
R. Jansen et al: “Antibiotics from gliding bacteria. LIX. Disorazoles, highly cytoxic metabolites from the sorangicin-producing bacterium Sorangium cellulosum, strain So ce12” Liebigs Annalen Der Chemie, Verlag Chemie GMBH. Weinheim, DE, 1994, pp. 759-773, XP002265587, ISSN: 0170-2041.
R. Jansen, et al: “Chivosazoles A-F: Novel Antifungal and Cytotoxic Macrolides fro Sorangium cellulosum (Myxobacteria)” Liebigs Ann./Recueil 1997 1725-1732.
Yeh, Tetrahedron report 698, Tetrahedrom 60 (2004) 11995-12042.
Wipf, Graham, “Total Synthesis of(-)-Disorazole Cl,” J. Am Chem. Soc. 2004, 126, 153456-7.
Hartung et al., “Toward the total synthesis for Disorazole A 1: Asymmetric synthesis of the masked northern half,” Synthesis 2003, No. 12, 1844-1850.
Haustedt et al., “Synthetic studies towards the disorazoles: Synthesis of a mask northern half of Disorazole D1 and a cyclopropane analog of the masked northern half of Disorazole A1 ,” Tetrahedrom 59 (2003) 6967-6977.
Hillier, Price, Meyers, “Studies on the total synthesis of Disorazole Cl. An advanced macrocycle intermediate,” J. Org. Chem. 2001 66,6037-6045, Table 1.
Scudiero, et al, “Evaluation of a Soluble Tetrazolium/Formazan Assay for Cell Growth and Drug Sensitivity in Culture Using Human and Other Tumor Cell Lines,” Cancer Research: 48, 4827-4833, Sep. 1, 1988.
Schmidt, et al, “Differential Modulation of paclitaxel-Mediated Apoptosis by p21Waf1and p27Kip1,” Oncogene (2000) 19, 2423-2429.

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