Biologically active compounds isolated from aerobic fermentation

Details Biologically active compounds isolated from aerobic fermentation Biologically active compounds isolated from aerobic fermentation

1993-02-09

1994-11-15

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554 35, 554 61, 554 63, 554213, 554218, 554227, 554228, 554229, 548469, 548534, C07C23300

Patent

active

053649486

ABSTRACT:
This invention relates to compounds of structural formula (I) isolated from an aerobic fermentation of Trichoderma viride MF5628, ATCC 74084: ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents. These compounds are also potent antifungal agents. Additionally, they inhibit farnesyl protein transferase and farnesylation of the oncogene protein Ras and are thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).

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