Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1992-09-03
1997-06-10
Cunningham, Thomas M.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
530300, 530350, 5303872, 53038827, 5303883, 4241851, 435 71, C07K 700, C07K 1414
Patent
active
056376774
ABSTRACT:
A method of constructing biologically active compounds which mimic the biological activity of the biologically active protein or which block the activity of the biologically active protein is disclosed. A method of identifying specific and discrete portions of pathogen antigens which either serve as epitopes for neutralizing antibodies or which are involved in pathogen binding to host cell receptors is disclosed. A method of constructing biologically active compounds which compete with cellular receptors for binding to either biologically active proteins or pathogen antigens is disclosed.
REFERENCES:
patent: 74264 (1868-07-01), Greene
patent: 4490358 (1984-12-01), Greene et al.
patent: 4683295 (1987-07-01), Carson
patent: 4761371 (1988-08-01), Bell et al.
Bruck, et al., "Nucleic Acid Sequence Of An Internal Image-Bearing Monoclonal Anti-Idiotype And Its Comparison To The Sequence Of The External Antigen", Proc. Natl. Acad. Sci. USA, 83:6578-6582, Sep. 1986.
Bassel-Duby, "Sequence Of Reovirus Hemagglutinin Predicts A Coiled-Coil Structure", Nature, 315:421-423 (1985).
Gaulton, et al., "Idiotypic Mimcry Of Biological Receptors", Ann. Rev. Immunol. 1986 4:253-280.
Gaulton, et al., "Anti-Idiotypic Antibody Identifies The Cellular Receptor Of Reovirus Type 3", Journal of Cellular Biochemistry, 28:69-78 (1985).
Gaulton, et al., "Syngeneic Monoclonal Internal Image Anti-Idiotopes As Prophylactic Vaccines", The Journal of Immunology, 137, 2930-2936 (Nov. 1, 1986).
Monroe, et al., "Anti-Idiotypic Antibodies And Disease", Immunological Investigations, 15(3) 263-286 (1986).
Smith, et al., Cancer Research, vol. 45, pp. 6119-6123 (Dec. 1985).
Thanavala, et al., J. Exp. Med., vol. 164, pp. 227-236 (Jul. 1986).
Chanh, et al., Proc. Natl. Acad. Sci. USA, vol. 84, pp. 3891-3895 (Jun. 1987).
Bruck, et al., Proc. Natl. Acad. Sci. USA, vol. 83, pp. 6578-6582 (Sep. 1986).
Fritz, et al., Journal of Immunology, vol. 128, pp. 247-250 (Jan. 1982).
Seiden, et al., Journal of Immunology, vol. 136, pp. 582-587 (Jan. 1986).
Budisavljevic, et al., Journal of Immunologuy, vol. 140, pp. 3059-3065 (May 1988).
WO, A, 8702990, Schering-Biotech, 21 May 1987. See (Dialog Database File 351, WPI Acct. No: 87-150613/21 XRAM Acc. No. C87-062883).
WO, A, 8807375 HIVER, 06 Oct. 1988. (Dialog Database File: 357 WPI Acc. No. 88-292708).
WO, A, 8809181 TANOX Biosystems IN. 01 Dec. 1988. (Dialog Database File: 351, WPI Acc. No. 88-353807/49. XRAM Acc. No. C88-156503.
EP, A, 241139 Merck and Co Inc. 14 Oct. 1987. (Dialog Database File: 351, WPI Acc. No. 87-285998/41, XRAM Acc. No. C87-121247.
Molecular and Cellular Biochemistry, vol. 65, pp. 5-21, Nov. 1984, C. N. Gaulton, et al., "Anti-Idiotypic Antiboides As Probes Of Cell Surface Receptors." Dialog Database File 155, Acc. No. 85110880.
Williams, et al. "Sequences of Cell Attachment Sites" PNAS 85: 6488-6492 (1985).
Gaulton, et al. "Inhibition of Cellular DNA Synthesis" J. of Exp. Med. 169:197-212 (1989).
Sun, et al. "Generation and Characterization of Monoclonal . . . " J. of Virology 63(9): 3579-3585 (1989).
Cantor and Schimmel Biophysical Chemistry Part 1, pp. 35-126.
Burstein, et al., "Evidence For Functional Domains On The Reovirus Type 3 Hemagglutinin", Virology, 117:146-155 (1982).
WO, A, 8807374 HIVER, 06 Oct. 1988 (Dialog Database File: 357, WPI Acc. No. 88-292708).
R. Arnon (editor), Synthetic Vaccines, vol. 1, 1987, CRC Press, Boca Raton, Florida (Dialog Database File 5, Biosis No. 35080391).
Lerner, R.A. et al. (editors), Vaccines 85, Cold Spring Harbor Laboratory, New York, 11724, published 1985, pp. 151-156.
London, et al., "Gut Mucosal Immunization With Reovirus Serotype I/L Stimulates Viral Specific Cytotoxic T Cell Precursors As Well As IgA Memory Cells In Peyer's Patches", (1987).
Rubin, et al., "Reovirus Serotype 1 Intestinal Infection: A Novel Replicative cycle With Ilead Disease", J. Virol., 53: 391-397 (1985).
Schneerson, et al., "Preparation, Characterization And Immunogenicity Of Hemophilus Influenzae Type b Polysaccaharide Protein Conjugates", J. Exp. Med. 152: 361 (1980).
Noseworthy, et al., "Cell Receptors For The Mammalian Reovirus. I. Syngeneic Monoclonal Anti-Idiotypic Antibody Identifies A Cell Surface Receptor For Reovirus", J. Immunol. 131: 2533-2538 (1983).
Goulton, et al., "Isolation And Biochemical Characterization Of The Mammalism Reovirus Type 3 Cell-Surface Receptor", Proc. Nat'l Acad. Sci. USA, 82: 1494-1498 (1985).
Spriggs, et al., "Topological Analysis Of The Reovirus Type 3 Hemagglutinin", Virology 127: 220-224 (1983).
Manemitsu, et al., "Biosynthesis Of Reovirus-Specified Polypeptides. Molecular cDNA Cloning and Nucleotide Sequence Of The Reovirus Serotype 1 Long Strain Bicistronic S1m RNA Which Encodes The Minor Capsid Polypeptide /a And The Nonstructural Polypeptide 16 NS", Biochem. Biophys. Res. Commun., 140: 501-510 (1986).
Weiss, et al., "Delayed Type Hypersensitivity To Mice Infected With Reovirus. Identification Of Host And Viral Gene Products Responsible For the Immune Response", J. Immunol., 125: 278-282 (1980).
Bassel-Duby, et al., "Identification Of Attenuating Mutations On The Reovirus Type 3 S1 Double-Stranded RNA Segment With A Rapid Sequencing Technique", J. Virol., 60: 64-67 (1986).
Kaye, et al., "Genetic Basis For Altered Pathogenesis Of An Immune-Selected Antigenic Variant Of Reovirus Type 3 (Dearing)", J. Virol., 59: 90-97 (1986).
Spriggs, et al., "Annenuated Reovirus Type 3 Strains Generated By Selection of Hemagglutinin Antigenic Variants", Nature (London) 297: 68-70 (1982).
Chou, et al., "Conformational Parameters For Amino Acids In Helical, Beta Sheet, And Random Coil Regions Calculated From Proteins", Biochemistry, 13(2): 211 (1974).
Institute of Medicine, "Vaccine Supply And Innovation", Nat'l Acad. Press (1985).
Jerne, "Towards A Network Theory Of The Immune System", Ann. Immunol. (Paris) 125: 337-389 (1974).
Sharpe, et al., "Synogenic Monoclonal Antiidiotype Can Induce Cellular Immunity To Reovirus", J. Exp. Med., 160: 195 205 (1984).
Kauffman, et al., "Cell Receptors For Mammalian Reovirus II Monoclonal Anti-Idiotypic Antibody Blocks Viral Binding To Cells," J. Immunol. 131: 2539-2541 (1983).
Ertl, et al., "Sendai Virus Specific T Cell Clones: Induction Of Cytolytic T Cells By An Anti-Idiotypic Antibody Directed Against A Helper T Cell Clone," Proc. Nat'l Acad. Sci. USA 81: 2850-2854 (1984).
Reagen, et al., "Anti-Idiotypic Antibodies Induce Neutralizing Antibodies To Rabies Virus Glycoproteins", J. Virol., 48: 660-666 (1983).
Uydeltaag, et al., "Induction Of Neutralizing Antibody In Mice Against Polio Virus Type II With Monoclonal Antiidiotypic Antibody," J. Immunol., 134: 1225-1229 (1985).
Elder, et al., "Localization Of Neutralizing Regions Of The Envelope Gene Of Feline Leukemia Virus By Using Anti-Synthetic Peptide Antibodies", J. Virol., 61:8-15 (1987).
Bowie, J.W., et al. Science 247:1306-1310 (1990), "Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions."
Briand, J.P., et al., J. Immunol. Meth. 78:59-69 (1985), "Synthetic Peptides as Antigens: Pitfalls of Conjugation Methods".
Bruck, C., et al., P.N.A.S. (USA) 83:6578-6582 (1986), "Nucleic Acid Sequence of an Internal Image-Bearing Monoclonal Anti-Idiotype . . . ".
Seiden, M.V., et al., J. Immunol. 136(2):582-587 (1986), "Hypervariable Region Peptides Induce Specific Anti-Idiotypic Antibodies . . . ".
Smith, L.J., et al., Cancer Res. 45:6119-6123 (1985), "Production of Heterologous Antibodies Specific for Murine B-Cell Leukemia (BCL,) Immunoglobulin by Immunization with Synthetic Peptides Homologous to Heavy Chain Hypervariable Regions."
Cohen Jeffrey A.
Greene Mark I.
Kieber-Emmons Thomas
Weiner David B.
Williams Robert M.
Colorado State University
Cunningham Thomas M.
The Trustees of the University of Pennsylvania
The Wistar Institute
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