Biologically active compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514468, 514721, 514763, 514766, 549356, 549458, 554229, 556400, 568 2, 568606, 568612, 568665, 568816, 568817, 568819, 568821, A01K 3135

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active

053995872

ABSTRACT:
The present invention relates to novel potassium channel agonists which are useful in activating the calcium activated Maxi-K potassium channel in mammalian neuronal and smooth muscle tissue. The claimed compounds are of the general formula: ##STR1## In addition, a novel microbiological process for producing the claimed compounds is described.

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Robertson et al., "Potassium Channel Modulators: Scientific Applications and Therapeutic Promise", J. Med. Chem. vol. 33, 1990, pp. 1529-1541.
Wantanabe et al. "CAF-603: A New Antifungal Carotane Sesquiterpene, Isolation and Structure Elucidation", J. Natural Products, vol. 53, 1990, p. 1176-1181.
Quagliato et al., "the Synthesis and Structural Characterization of WAY-120,491, A Novel Potassium Channel Activator", Bioorganic & Medicinal Chemistry Letters, vol. 1, 1991, pp. 39-42.
McManus, O. B. et al. "An Activator of Calcium-Dependent Potassium Channels Isolated from a Medicinal Herb", Biochemistry, vol. 32, No. 24, pp. 6128-6133 (1993).
Watanbe et al., Journal of Natural Products, vol. 53, #5, pp. 1176-1181, 1990.

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