Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1990-06-22
1993-06-15
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424 9, 424 88, 424 89, 424490, 424493, 514770, 514951, 514970, A61K 916
Patent
active
052195775
ABSTRACT:
A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically active proteins, peptides or pharmacological agents to the microparticles. When viral protein is attached to the core particles, the result is a viral decoy which accurately mimics the native virus in both size and structure while being entirely devoid of virulent activity due to the microparticle core. Other antigenic proteins or peptides are attached to provide molecules which are useful in raising antibodies or as a diagnostic tool. Further, pharmacological agents are attached to the microparticles to provide pharmaceutical compositions.
REFERENCES:
patent: 4225581 (1980-09-01), Kreuter et al.
patent: 4329332 (1982-05-01), Couvreur et al.
patent: 4744760 (1988-05-01), Molday
Hayashi, C., Ultrafine Particles, J. Vac. Sci. Technol. A5(4), Jul./Aug. 1987 pp. 1375-1384.
Eastman, J. et al., Nanophase Synthesis Assembles Materials From Atomic Clusters, Res. & Dev. Jan. 1989, pp. 56-60.
Matijevic E., Fine Particles Part II, MRS Bulletin, Jan. 1990, pp. 16-49.
Kvalheim, G., Immunomagnetic Removal of B-Lymphoma Cells . . . , Bone Marrow Transplantation (1989), 4, pp. 567-574.
Varga, J. M., Immobilization of Small Molecules and Proteins. . . , FASEB Journal, vol. 4 Jun. 1990, pp. 2671-2677.
Juliano, R. L. (Ed) Biological Approaches to the Controlled Delivery of Drugs, Anals of NY Acad of Sci. vol. 507, pp. 104-141, pp. 211-219 and 252-280.
Faulk, et al., An Immunocolloid Method for the Electron Microscope, Immunochemistry, vol. 8, 1971, pp. 1081-1083.
Hainfeld, J. F., Gold Cluster-Labelled Antibodies, Nature vol. 333, May 1988 pp. 281-282.
Harven, E. et al., A Novel Approach for SEM of Coll. Goldlabelled Cell Surfaces, Journ. of Cell Biol., vol. 99, Jul. 1984, pp. 53-57.
Hsu, Y., Immunogold for Detection of Antigen on Nitrocellulose paper, Anal. Bioch., 142, 221-225 (1984).
Randall, R. E., Solid Matric-antibody-antigen . . . , Immunology Today, vol. 10, No. 10, 1989 pp. 336-339.
Johansson, M. E. et al., Prep. of Specific Antisera Against Adenoviruses . . . , Journ. of Immun. Methods, 26(1979) 141-149.
Warren, H. S. et al., Current Status of Immunological Adjuvants, Ann. Rev. Immunol. 1986 4:369-388.
Davis, S. S., Polymerica Microspheres as Drug Carriers, Biomaterials, 1988, vol. 9, Jan. pp. 111-115.
Zymed Brochure-Immunochemical Products-1989.
Advanced Magnetics, Inc. Brochure-Research Products 1988-1989.
Dynal AS Brochure--Immunomagnetic Separations Using DYNABEADS.RTM.--undated.
Kubiak, C., Couvreur, P. Manil, L., Clausse, B., "Increased cytotoxicity of nanoparticle-carried Adriamycin in vitro and potentiation by verapamil and amiodarone", Biomaterials 1989, vol. 10, Oct. pp. 553-556.
Manil, L., Roblot-Treupel, L., Couvreur, P., "Isobutyl cyanoimmunoradiometric assay", Biomaterials 1986, vol. 7 May 1986, pp. 212-216.
Couvreur, P., Kante, B., Lenaerts, V., Scailteur, V., Roland, V., and Speiser, P., "Tissue Distribution of Antitumor Drugs Associated with Polyalkylcyanoacrylate Nanoparticles", Jour. of Pharm. Sci. vol. 69, No. 2, Feb. 1980, pp. 199-202.
Couvreur, P., Kante, B., Roland, M., Guio, P., Bauduin, P., Speiser, P. "Communications", J. Pharm. Pharmacol. 1979, 31:331-332.
Pyle, Stephen W., et al., "Immune response to immunostimulatory complexes . . . ", Vaccine, vol. 7, Oct. 1989, pp. 465-473.
Lovgren, Karin, and Morein, Bror, "The Iscom: An Antigen Delivery System with Built-In Adjuvant", Molecular Immun., vol. 28, No. 3, pp. 285-286, 1991.
Morein, B., "Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses", Letters to Nature, Mar. 1984, pp. 457-460.
Morein, Bror, "The iscom: an Immunostimulating System", Immunology Letters, 25 (1990) pp. 281-284.
Bunshah Rointan F.
Kossovsky Nir
Page Thurman K.
Spear James M.
The Regents of the University of California
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