Biologically active catecholamine derivatives

Details Biologically active catecholamine derivatives Biologically active catecholamine derivatives

1980-09-04

1982-06-29

Demers, Arthur P.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260404, 562444, 564165, 424309, 424324, C07C10329

Patent

active

043372074

ABSTRACT:
Biologically active derivatives of norepinephrine are disclosed. Such derivatives are catecholamines wherein isoproterenol is modified by extending the isopropyl functional grouping to an alkyl, aryl, or alkyl-aryl chain of variable length where said chain terminates in a carboxylic acid functional group, or in a substituted amide functional group. Such derivatives are .beta.-adrenergic and a number of such derivatives e.g., 6-(.beta.-3,4-dihydroxyphenyl-.beta.-hydroxy)-ethylamino heptanoic acid p-toluide, 6-(.beta.-3,4-dihydroxyphenyl-.beta.-hydroxy)-ethylamino heptanoic acid para-n-butyl anilide; 6-(.beta.,3,4-dihydroxyphenyl-.beta.-hydroxy)-ethylamino heptanoic acid para-methoxy anilide; 6-(.beta.-3,4-dihydroxyphenyl-.beta.-hydroxy)-ethylamino heptanoic acid paratrifluoromethyl anilide; and 6-(.beta.-3,4-dihydroxyphenyl-.beta.-hydroxy)-ethylamino heptanoic acid N-methyl para-toluide display a .beta.-adrenergic activity at least several orders of magnitude greater than isoproterenol itself. Several methods of producing such active derivatives are also disclosed.

REFERENCES:
patent: 3732300 (1973-05-01), Lunts et al.
patent: 4146638 (1979-03-01), Renth et al.
Wagner et al., Synthetic Organic Chemistry, John Wiley & Sons, N.Y., N.Y., 1955, pp. 660-661.

Affiliated with

Also associated with

Rating

Biologically active catecholamine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biologically active catecholamine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biologically active catecholamine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2164530