Biologically active bactericidal/permeability-increasing protein

Details Biologically active bactericidal/permeability-increasing protein Biologically active bactericidal/permeability-increasing protein

1993-12-23

1996-11-19

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530324, A61K 3816

Patent

active

055762921

ABSTRACT:
Disclosed herein are methods of inhibiting the endotoxin-mediated release of cytokines in a mammal by administering a 30 kD C-terminal fragment of bactericidal/permeability-increasing protein. The disclosed fragments are useful to treat mammals suffering from infections caused by gram-negative bacteria.

REFERENCES:
patent: 5089274 (1992-02-01), Marra et al.
patent: 5198541 (1993-03-01), Elsbach
Tobias et al., J. Biol. Chem., 263:13479-13481, 1988.
Marra et al., J. Immunol., 144:662-666, 1990.
Weiss et al., Blood, 69:652-659, 1987.
Mannion et al., J. Immunol., 142:2807-2812, 1989.
Gray et al., J. Biol. Chem., 264:9505-9509, 1989.
Tobias et al., J. Biol. Chem., 264:10867-10871, 1989.
Veld et al., Infection and Immunity, 56:1203-1208, 1988.
Elsbach, Trends in Biotechnology, 8:26-30, 1990.
Weiss et al., Infection and Immunity, 51:594-599, 1986.
Farley et al., Infection and Immunity, 56:1589-1592, 1988.
Weiss et al., J. Clin. Invest., 65:619-628, 1980.
Weiss et al., Infection and Immunity, 38:1149-1153, 1982.
Weiss et al., J. of Immunol., 132:3109-3115, 1984.
Weiss et al., J. Clin. Invest., 71:540-549, 1983.
Weiss et al. J. Biol. Chem. vol. 253 No. 8 (1978).
Ooi et al. J. Biol. Chem. vol 262 No. 31 (Nov. 5, 1987) 14891-14894.
Weiss et al. (Abstract, The American Federation for Clinical Research May 2, 3, 4, & 5 1986).

Affiliated with

Also associated with

Rating

Biologically active bactericidal/permeability-increasing protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biologically active bactericidal/permeability-increasing protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biologically active bactericidal/permeability-increasing protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-541011