Biologically active analogs of ACTH and radioimmuno assay theref

Details Biologically active analogs of ACTH and radioimmuno assay theref Biologically active analogs of ACTH and radioimmuno assay theref

1981-05-12

1983-11-15

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

2601125R, 424 9, G01N 3356, G01N 3358, C07C10352

Patent

active

044155468

ABSTRACT:
A fully steroidogenically active analog of ACTH is disclosed. The analog differs from natural ACTH in that phenylalanine replaces tyrosine in the second position on the peptide chain; and norleucine replaces methionine in the fourth position on the peptide chain. The analog may be iodinated to yield [I]Tyr.sup.2 -Phe.sup.2,Nle.sup.4 -ACTH, which also retains full steroidogenic activity. When labeled with iodine-125 the analog is useful in following steroidogenic processes and also in radioimmunoassays for ACTH.

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