Biologically active amides containing a bicyclo moiety

Details Biologically active amides containing a bicyclo moiety Biologically active amides containing a bicyclo moiety

1994-08-03

1995-12-19

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40704

Patent

active

054769531

ABSTRACT:
Cytotoxic metabolites are isolated by extraction and chromatography from a marine sponge of the same species as that deposited in the Zoological Museum of the University of Amsterdam under reg. no. ZMA POR. 10883. The isolated compounds belong to the genus of compounds having the structure: ##STR1## wherein R is C.sub.6 -C.sub.12 alkyl or C.sub.6 -C.sub.12 alkenyl having 1 or 2 double bonds, which may be interrupted with one or more imino groups and which may be substituted with one or more substituents selected from the group consisting of amino, carboxyl, hydroxy, imino and oxo.

REFERENCES:
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Fusetani N., et al, J. Org. Chem. 57, 3828-3832 (1992).
Perry, N. B., et al, J. Am. Chem. Soc., 110, 4850-4851 (1988).
Perry, N. B., et al, J. Org. Chem., 55, 223-227 (1990).
Sakemi, S., et al, J. Am. Chem. Soc. 110, 4851-4853 (1988).

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