Biologically active alternative form of the ikka.alpha. I.kappa.

Details Biologically active alternative form of the ikka.alpha. I.kappa. Biologically active alternative form of the ikka.alpha. I.kappa.

1998-09-25

2000-07-04

Achutamurthy, Ponnathpu

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

4353201, 4353523, 435325, 536 232, C12N 912, C12N 120, C12N 1500, C12N 500, C12N 2104

Patent

active

060837322

ABSTRACT:
The present invention provides an isolated I.kappa.B kinase designated IKK.alpha..DELTA.C, that regulates NF.kappa.B gene transcription. IKK.alpha..DELTA.C is an I.kappa.B protein kinase having a kinase domain, a leucine zipper like .alpha.-helix domain, and no helix-loop-helix domain. Also provided are the amino acid sequence of IKK.alpha..DELTA.C, the nucleotide sequence encoding IKK.alpha..DELTA.C, and other related protein and nucleic acid molecules. The invention provides antibodies specific for IKK.alpha..DELTA.C and methods of using the IKK.alpha..DELTA.C proteins of the invention in the development of antiinflammatory agents or immunosuppressants.

REFERENCES:
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patent: 5804374 (1998-09-01), Baltimore et al.
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Margery A. Connelly and Kenneth B. Marcu, "CHUCK, a New Member of the Helix-Loop-Helix and Leucine Zipper Families of Interacting Proteins, Contains a Serine-Theronine Kinase Catalytic Domain", Cellular and Molecular Biology Research vol. 41:537-549 (1995).
DiDonato et al., "A Cytokine-Responsive I.kappa.B Kinase That Activates The Transcription Factor NF-.kappa.B", Nature 388:548-554 (1997).
Regnier et al., "Identification and Characterization of an I.kappa.B Kinase", Cell vol. 90:373-383 (1997).
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Zandi et al., "The I.kappa.B Kinase Complex (IKK) Contains Two Kinase Subunits, IKK.alpha. and IKK.beta., Necessary for I.kappa.B Phosphorylation and NF-.kappa.B Activation", Cell vol. 91: 243-252 (1997).

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