Biologically active acylated amino acid derivatives

Details Biologically active acylated amino acid derivatives Biologically active acylated amino acid derivatives

1994-03-25

1997-04-15

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142278, 5142315, 514261, 514300, 514315, 514316, 514318, 514326, 514422, 514408, 544 584, 544130, 544277, 548517, 548572, 540596, 540597, 540598, 540599, 540600, 540601, 540602, 546113, 546189, 546193, 546199, 546212, 546213, A61K 3154, A61K 31535, C07D40314, C07D40306

Patent

active

056209711

ABSTRACT:
The present invention relates to novel compounds which possess a broad range of useful biological activities. These compounds can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. They can also suppress, modify, or significantly reduce an immune response, including an autoimmune response in a mammal. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, for use in multi-drug resistant cancer therapy, and for prevention or treatment of graft rejection and various autoimmune diseases.

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