Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-10-26
1986-09-16
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514265, 544269, 544271, 544273, A61K 3141, C07D47306
Patent
active
046123156
ABSTRACT:
Certain functionalized congeners of 1,3-dialkylxanthine exhibit high potency and selectivity as antagonists for A.sub.1 - and A.sub.2 -adenosine receptors and are suitable for attachment to probes, drug carriers, or solid supports. These derivatives are characterized by the presence of a phenyl at the 8 position para-substituted with a functionalized chain to provide high water solubility and high receptor affinity to such an extent that these compounds are suitable for use as antiallergenic, antiasthmatic, or cardiotonic drugs, central nervous system stimulants, and diuretics.
REFERENCES:
patent: 4397779 (1983-08-01), Groman
Bruns, Proc. Natl. Acad. Sci., USA, 80, pp. 2077-2080, (4/83).
Daly John W.
Jacobson Kenneth A.
Kirk Kenneth L.
Benson Robert
Daus Donald G.
Roberts, Jr. John S.
The United States of America as represented by the Department of
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