Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Patent
1996-10-30
1999-02-23
Marschel, Ardin H.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
422 50, 422 62, 422 63, 422 67, 422 69, 422 8201, 422 8202, 436501, 435 6, 435 29, 435 30, 435 405, 4352831, 4352851, 4352852, 4352871, 4352872, 4352873, 4352891, 935 77, 935 78, 935 88, G01N 2730, G01N 27327, G01N 27406
Patent
active
058740465
ABSTRACT:
A sensor system and method are provided that are capable of the real-time detection of target live microorganisms, such as biological warfare agents. The sensor system includes a highly-sensitive, highly-selective sensor cell that comprises a single-stranded oligonucleic acid sequence that is complementary to a portion of the DNA of a target live microorganism, the oligonucleic acid having been modified with the covalent attachment of electron donor and acceptor moieties. In the presence of the targeted microorganism, hybridization occurs between the modified oligonucleic acid and the microorganism's DNA, such that the electron conductance between the electron transfer moieties greatly increases, thereby providing a means of detecting the presence of the target live microorganism. Aside from the sensor cell, the sensor system also includes an inlet port in the sensor cell wall by which to introduce a sample from the fluid environment into the sensor cell; a cell wall disrupter to release the nucleic acid of the fluid sample into the sensor cell; an electron transfer rate measuring system to gauge the electron transfer rate between the electron transfer moieties of the modified oligonucleic acid; a power source; a microcontroller to analyze the measured electron transfer rate for evidence of hybridization; and a communication system for relaying information regarding the presence or absence of the target live microorganism to the user of the sensor system. It is contemplated that the sensor system, exclusive of a battery and pump pack, will be only slightly larger than a pack of cigarettes and light enough to be comfortably worn and carried by personnel.
REFERENCES:
patent: 4840893 (1989-06-01), Hill et al.
patent: 5591578 (1997-01-01), Meade et al.
patent: 5632957 (1997-05-01), Heller et al.
T.J. Meade et al, "Electron Transfer through DNA: Site-Specific Modification of Duplex DNA with Ruthenium Donors and Acceptors", Angewandte Chemie, International Edition in English, vol. 34, No. 3, pp. 352-354 (Feb. 21, 1995).
Alkov Leonard A.
Lenzen, Jr. Glenn H.
Marschel Ardin H.
Raufer Colin M.
Raytheon Company
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