Biological tissue transplant coated with stabilized multilayer a

Details Biological tissue transplant coated with stabilized multilayer a Biological tissue transplant coated with stabilized multilayer a

1996-11-26

1999-03-02

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

264 41, 435182, 43524022, 435240241, 435240243, 623 11, A61F 202, A01N 102, C12N 508

Patent

active

058767428

ABSTRACT:
A biological tissue transplant coated with a stabilized multilayer alginate coating and a method for preparation of the stabilized multilayer coating. Coating has three primary layers of the alginate with a polyamino acid barrier emplaced between a primary and a secondary layer. The secondary "halo" layer of soft gel is formed by a gel gradient created between weakly bound cross-linking gelling divalent cations of an alginate used for the primary layer of the coating and non-gelling counter ions of a non-ionic alginate of the secondary layer of the coating.

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