Biological system for constructing and testing viral vaccines

Details Biological system for constructing and testing viral vaccines Biological system for constructing and testing viral vaccines

1989-12-22

1993-05-18

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

4352351, 435236, 4353201, 435238, C12Q 170, C12N 1500

Patent

active

052120570

ABSTRACT:
Disclosed is a novel biological system for 1) the evaluation of potential complications of live virus vaccines prior to actual testing in animals or in the field, and 2) the construction of vaccine vectors in which the ability to grow within specific organs or tissues has selectively been eliminated from the virus.

REFERENCES:
patent: 4769330 (1988-09-01), Paoletti et al.
Panicali et al., Proc. Natl. Acad. Sci. U.S.A., vol. 80, pp. 5364-5368, Sep. 1983, "Construction of Live Vaccines by Using Genetically Engineered Poxviruses: Biological Activity of Recombinant Vaccinia Virus Expressing Influenza Virus Hemagglutinin."
Rodriguez et al., J. Virol., vol. 61, No. 11, Nov. 1987, pp. 3550-3554, "Mapping and Nucleotide Sequence of the Vaccinia Virus Gene that Encodes a 14-Kilodalton Fusion Protein".
Piccini, A., and E. Paoletti (1986) "The use of vaccinia virus for the construction of recombinant vaccines," Bioessays 5:248-252.
Brown, F., G. C. Schild, and G. L. Ada (1986) "Recombinant vaccinia viruses as vaccines," Nature 319:549-550.

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