Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1992-03-12
1995-12-12
Moskowitz Parr, Margaret
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
424530, 43524021, 435240243, 435 11, 435214, 514 12, 530381, 530382, 623 15, C12N 508, C07K 14745, A01N 102, A61F 210
Patent
active
054747708
ABSTRACT:
The present invention relates to a biological support for cell cultures formed by the coagulated mixture of a concentrate of plasma proteins and thrombin.
The protein concentrate is obtained by precipitating fresh plasma with ethanol and contains balanced proportions of fibrinogen, Factor XIII and fibronectin. The thrombin concentration is adjusted to obtain the desired consistency of the support coagulated in the form of a film.
The biological support is preferably used for preparing a culture of keratinocytes, recovering them in the form of a reconstituted tissue and transporting same. The reconstituted tissue is thus particularly suitable for use as a graft.
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Nuzzolo, et al. Tissue Culture Techniques pp. 84-85 Warren H. Green, Inc. St. Louis, Mo. 1983.
Hunyadi, et al. Keratinocyte Transplantation: Covering of Skin Defects by Autologous Keratinocytes.
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Cohn et al. Preparation and Properties of Serum and Plasma Proteins IV. J. American Chemical Society vol. 68 pp. 459-475 Mar., 1946.
Search Report from FR 88 15950.
Ronfard et al., "Use of human keratinocytes . . . treatment of burn wounds," Burns, (1991) vol. 17, No. 3, pp. 181-184.
Broly Herve
Ronfard Vincent
Centre Regional de Transfusion Sanguine de Lille
Moskowitz Parr Margaret
Schwadron Ron
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