Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Patent
1989-01-18
1991-09-10
Warden, Robert J.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
422 8205, 422 57, 422 681, 422 58, 436164, 356318, 356445, G01N 2100, G01N 2155
Patent
active
050472135
ABSTRACT:
A biological sensor which utilizes the phenomenon of surface plasmon resonance to detect the refractive index change which occurs when two components--for example antibody and corresponding antigen--react with one another. Surface plasmon resonance takes place at the sloping exit surface of an optical waveguide such as a fiber optic 23. The input end of fiber optic 12 is connected to a light source 12. A layer 25 of metal is applied to the sloping exit surface so as to cause total internal reflection of the light proceeding down the fiber optic. Reflected light is detected by a detector 13. A sensitive, for example antibody, layer 26 is applied to the metal layer. Sample (not shown) reacts with layer 26 in such a way that the refractive index changes. Provided conditions are correct, this variation in refractive index can be monitored in detector 13 by virtue of the surface plasmon resonance which occurs in the area of total internal reflection.
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"Sensors and Actuators", vol. 4, pp. 299-304 (1983).
Finlan Martin F.
Harvey Richard P.
Amersham International plc
Trembley Theresa A.
Warden Robert J.
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