Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Patent
1989-05-30
1991-10-08
Warden, Robert J.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
422 681, 422 8209, 422 66, 356318, 356445, 436 44, 436805, 435808, G01N 2100, G01N 2155
Patent
active
050552651
ABSTRACT:
The present invention is drawn to a surface plasmon resonance (SPR) sensor in which the phenomenon of long-range surface plasmon resonance is used to develop a highly sensitive detector for use in biological, biochemical or general chemical testing. The sensor includes a laminar structure having of a high refractive index glass block, a membrane of dielectric material, a thin metal layer, and a sensitive layer. A sample to be tested is brought into contact with the sensitive layer. The refractive index of the dielectric layer and that of the layer (sensitive layer/sample) on the opposite side of the metallic layer should be equal, or nearly so, and the refractive index of the glass block should be higher than this so that total internal reflection takes place at the interface between the block and the membrane. Light from a laser source is totally internally reflected at this interface, and the strength of the reflected beam is monitored by a light detector. Provided conditions are correct, long-range SPR will take place which will sensitively alter the strength of the light in dependence upon the progress of the reaction between the sensitive layer and sample.
REFERENCES:
patent: Re30627 (1981-05-01), Bagshawe et al.
patent: 3526480 (1970-09-01), Findl et al.
patent: 4844613 (1989-07-01), Batchelder et al.
patent: 4857273 (1989-08-01), Stewart
patent: 4877747 (1989-10-01), Stewart
patent: 4883642 (1989-11-01), Bisconte
"Surface Plasmon Resonance for Gas Detection and Biosensing", Liedberg et al., Sensors and Actuators, 4 (1983), pp. 299-304.
"Experimental Observation of the Long-Range Surface-Plasmon Polariton", Craig et al., Optics Letters, vol. 8, No. 7, Jul. 1983, pp. 380-382.
"Long-Range Surface-Plasmon Modes in Silver and Aluminum Films", Quail et al., Optics Letters, vol. 8, No. 7, Jul. 1983, pp. 377-379.
Amersham International plc
Trembley Theresa A.
Warden Robert J.
LandOfFree
Biological sensors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biological sensors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biological sensors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-255904