Biological regulation of mineralization

Details Biological regulation of mineralization Biological regulation of mineralization

1991-06-10

1994-04-19

Wax, Robert A.

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

435 71, 514 8, 514 12, 514 14, 514 891, 530324, 530327, 530350, 530395, 530834, 530835, 530840, G01N 3353, A61K 3702, C07K 710, C07K 708

Patent

active

053044967

ABSTRACT:
An aspartic acid rich protein isolated from human urine, as well as proteins having substantial homology thereto and active portions of the foregoing are effective modulators of mineralization in mammals. These proteins and peptides are useful as therapeutic agents, such as in the treatment of kidney stone disease. Hybridoma cell lines capable of producing monoclonal antibodies to these proteins and peptides and monoclonal antibodies produced by these hybridomas are disclosed. These monoclonal antibodies are also useful as therapeutic agents, such as in the treatment of osteoporosis, and further have utility as diagnostic agents. Other uses are also described.

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