Biological preparations

Details Biological preparations Biological preparations

1979-03-30

1980-04-01

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

A61K 3912

Patent

active

041961919

ABSTRACT:
A novel antigenic preparation which comprises a plurality of microvesicles which microvesicles are unilamellar bodies comprising a single lipid bilayer upon the exterior surface of which is bound an antigenic protein derived from a virus and having a hydrophobic region.

REFERENCES:
patent: 4117113 (1978-09-01), Allison et al.
patent: 4148876 (1979-04-01), Almeida et al.
Van Rooijen et al., Immunol. Commun. 1977 6(5): 489-498 Liposomes in Immunology: The Immune Response Against Antigen-Containing Liposomes.
Wilson et al., Proc. Natl. Acad. Sci. U.S.A. 1977 74(8): 3471-3475 Biological Properties of Polio Virus Encapsulated in Lipio Vesicles.
Van Rooijen et al., Immunol. Commun. 7(6): 635-644 (1978), Liposomes in Immunology: Further Evidence for the Adjuvant Activity of Liposomes.
Manesis et al., Biochem. Soc. Trans. 6(5): 925-928 (1978) Incorporation of Hepatitis B Surface Antigen (HB.sub.5 AG) into Liposomes.

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