Optics: measuring and testing – By polarized light examination – With polariscopes
Patent
1989-01-26
1989-12-05
Westin, Edward P.
Optics: measuring and testing
By polarized light examination
With polariscopes
250225, G01J 400
Patent
active
048848867
ABSTRACT:
An apparatus and method for making multiparameter light scattering measurements from suspensions of biological particles is described. Fourteen of the sixteen Mueller matrix elements describing the particles under investigation can be substantially individually determined as a function of scattering angle and probing radiations wavelength, eight elements simultaneously for each of two apparatus configurations using an apparatus which incluees, in its simplest form, two polarization modulators each operating at a chosen frequency, one polarizer, a source of monochromatic electromagnetic radiation, a detector sensitive to the wavelength of radiation employed, eight phase-sensitive detectors, and appropriate electronics. A database of known biological particle suspensions can be assembled, and unknown samples can be quickly identified once measurements are performed on it according to the teachings of the subject invention, and a comparison is made with the database.
REFERENCES:
patent: 3612688 (1971-10-01), Liskowitz
patent: 3785735 (1974-01-01), Friedman et al.
patent: 3817634 (1974-06-01), Barron
patent: 4140902 (1979-02-01), Young
patent: 4306809 (1981-12-01), Azzam
Salzman, Gary, "Light Scattering Analysis of Single Cells", Cell Analysis, ol. 1, Plenum Pub. Co., 1982, pp. 111-143.
Bickel et al, "Polarized Light Scattering from Biological Systems: A Technique for Cell Differentiation", J. Biol. Physics, vol. 9, 1981, pp. 53-66.
Bickel et al, "Application of Polarization Effects in Light Scattering: A New Biological Tool", Proc. Nat. Acad. Sci., vol. 73, No. 2, pp. 486-490, Feb. 1976.
Salzman et al., "Rapid Indentification of Microoroganisms by Circular-Intensity Differential Scattering", App. and Eviron. Microbiology, Nov. 1982, pp. 1081-1085.
Azzam, "Photopolarimetric Measurement of the Mueller Matrix by Fourier Analysis of Single Detected Signal", Optical Letters, vol. 2, No. 6, Jun. 1978, pp. 148-150.
Hunt et al., "A New Polarization-Modulated Light Scattering Instrument", Rev. Sci. Instrum., vol. 44, No. 12, Dec. 1973, pp. 1753-1762.
Azzam, "Simulation of Mechanical Rotation by Optical Rotation", J. Opt. Soc. Am., vol. 68, No. 4, 1978, pp. 518-520.
Thompson et al., "Measurement of Polarized Light Interactions via the Mueller Matrix", Applied Optics, vol. 19, No. 8, pp. 1323-1332.
Grace W. Kevin
Gregg Charles T.
Hiebert Richard D.
Salzman Gary C.
Freund Samuel M.
Hightower Judson R.
The United States of America as represented by the Department of
Westin Edward P.
Wilson Ray G.
LandOfFree
Biological particle identification apparatus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Biological particle identification apparatus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biological particle identification apparatus will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2031049