Biological mediators of immune functions

Details Biological mediators of immune functions Biological mediators of immune functions

1992-11-13

1995-04-04

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530328, 530350, 5303871, 424569, A61K 3702, C07K 500, C07K 700, C07K 1500

Patent

active

054039142

ABSTRACT:
A chemotactic factor released from tissue in response to injury represents the initial signal that recruits neutrophils to the tissue. As released, the factor exists as a positively charged protein complex consisting of a low molecular weight active peptide factor that carries a neutral to negative charge and a weakly associated high molecular weight protein. The tissue derived complex exhibits a molecular weight of about 100,000-300,000 daltons and the factor is obtained therefrom and purified. The peptide factor is non-immune cell derived and non-serum derived and exhibits a molecular weight of approximately 3,000 daltons.

REFERENCES:
patent: 4797277 (1989-01-01), Arfors
Elgebaly et al., Eleventh Int. Res. Congress, Oct. 17-21, 1987.
Kozol et al., American Gastroenterological Asso., "Gasteric-Derived Leukocyte Chemotactic Factors: Initial Characterization" May 10-13, 1987.
Elgebaly et al., AJP, pp. 40-50, 1987.

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