Biological materials

Details Biological materials Biological materials

1978-08-07

1980-09-30

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, A61K 3912

Patent

active

042255813

ABSTRACT:
There are described processes for the preparation of submicroscopic particles of physiologically acceptable polymer associated with a biologically active material, by polymerizing a monomer in the presence of the biologically active material or by adsorbing the biologically active material upon preformed submicroscopic polymer particles. Where the biologically active material is an antigen, the particles are useful as constituents of injectable vaccines having an adjuvant effect.

REFERENCES:
patent: 4021364 (1977-05-01), Speiser et al.
patent: 4107288 (1978-08-01), Oppenheim et al.
Birrenbach, G., Diss. Eth Zurich (1973), pp. 62ff. "Uber Mizellpolymerisate, Mogliche Ein Schlussver Bindungen (Nanokaplsen) und Deren Gignung", Als Adjuvantion.
Kreuter, J., Diss. Eth Zurich (1974), pp. 23ff. "Neue Adjuvantion Auf Polymethyl Methacrylat Basis".
Birrenbach et al., J. Pharm. Sci. 65(12): 1763-1766 Dec. 1976, "Polymerized Micelles and Their Use as Adjuvants in Immunology".
Kreuter et al., J. Pharm. Sci. 65(11): 1624-1627 Nov. 1976, "In Vitro Studies of Poly(Methyl Methacrylate) Adjuvants".
Kreuter Pharm. Acta. Helv. 53(2): 33-39 (1978), "Nanoparticles and Nanocapsules-New Dosage Forms in the Nanometer Size Range".
Kreuter et al., Expl. Cell. Biol. 44:12-19 (1976), "The Use of New Polymethyl Methacrylate Adjuvants for Split Influenza Vaccines".
Kreuter et al., Infection & Immunity 13(1): 204-210, Jan. 1976, "New Adjuvants on a Polymethylmethacrylate Base".
Marty et al., Australian J. Pharm. Sci. 6(3): 65-75, Sep. 1977, "Colloidal Systems for Drug Delivery".
Marty et al., Pharm. Acta Helv. 53(1): 17-23 (1978), " Nanoparticles-A New Colloidal Drug Delivery System".

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