Biological materials

Details Biological materials Biological materials

1980-05-02

1981-05-26

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

424 22, 424 32, 424 33, 424 81, 424177, A61K 3726, A61K 914, A61K 952, A61K 958

Patent

active

042698219

ABSTRACT:
There are described processes for the preparation of submicroscopic particles of physiologically acceptable polymer associated with a biologically active material, by polymerizing a monomer in the presence of the biologically active material or by adsorbing the biologically active material upon preformed submicroscopic polymer particles. Where the biologically active material is an antigen, the particles are useful as constituents of injectable vaccines having an adjuvant effect.

REFERENCES:
patent: 4021364 (1977-05-01), Speiser et al.
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4225581 (1980-09-01), Kreuter et al.
Marty et al., Pharm. Acta. Helv. 53(1):17-23 (1978) Nanoparticles-A New Colloidal Drug Delivery System.
Marty et al., Australian J. Pharm. Sci. 6(3):65-75, Sep. 1977, Colloidal Systems for Drug Delivery.
Kreuter, Pharm. Acta. Helv. 53(2):33-39 (1978) Nanoparticles and Nanocapsules-New Dosage Forms in the Nanometer Size Range.
Birrenbach, G., Diss. Eth Zurich (1973) p. 62ff, Uber Mizellpolymerisate Mogliche ein Schlussver Bindungen (Nanokapseln) und Deren Gignung Als Adjuvantion.

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