Bleaching and dyeing; fluid treatment and chemical modification – Treatment of hides – skins – feathers and animal tissues – Internal tissues
Patent
1994-04-18
1997-01-21
Kalafut, Stephen
Bleaching and dyeing; fluid treatment and chemical modification
Treatment of hides, skins, feathers and animal tissues
Internal tissues
623 1, 623 2, 623 11, 623 12, 623 13, 623 14, A61L 1700, D01C 300, A61F 202
Patent
active
055955711
ABSTRACT:
Disclosed is a controlled autolysis method for making biological tissue substantially acellular by exposing the biological material, prior to any fixation thereof, to at least one buffered solution having a pH in the range from about 5.0 to 8.0 and a temperature in the range from about 12.degree. C. to 30.degree. C. for a sufficient period of time to render at least one region of the biological material substantially acellular while substantially preserving the structural integrity and non-cellular structural components of the biological material. Also disclosed is a method of making a bioprosthetic heart valve using biological material that has been treated by controlled autolysis and a method of treating a mammal having a defective heart valve using a bioprosthetic heart valve made, in part, by controlled autolysis.
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Hancock Warren B.
Jaffe Norman
Diamond Alan D.
Hancock Jaffe Laboratories
Kalafut Stephen
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