Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Reexamination Certificate
2003-09-11
2010-06-22
Jiang, Shaojia Anna (Department: 1623)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
C424S422000, C424S078270, C514S801000, C604S368000
Reexamination Certificate
active
07741454
ABSTRACT:
The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized artificially. Thus, they are not metabolized in vivo and exhibit toxicity to living bodies. These compounds are thus used only in a restricted amount and for limited purposes in the clinical sites. The present invention provides a biological low-molecular-weight derivative obtained by modifying carboxyl groups of a biological low-molecular-weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide, or a derivative thereof and a crosslinked high-molecular-weight product obtained by crosslinking various high-molecular-weight compounds with this derivative.
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Kobayashi Hisatoshi
Saito Hirofumi
Taguchi Tetsushi
Tanaka Junzo
Furuuchi Chemical Corporation
Goon Scarlett
Jiang Shaojia Anna
National Institute for Materials Science
Westerman Hattori Daniels & Adrian LLP
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