Biological liquid fractionation using alternate opposite flow di

Details Biological liquid fractionation using alternate opposite flow di Biological liquid fractionation using alternate opposite flow di

1980-10-31

1982-08-10

Hruskoci, Peter A.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210651, 210805, 2101952, 2102572, 210422, 2104332, 210443, 210445, B01D 1300, B01D 3100

Patent

active

043437052

ABSTRACT:
A fractionation system for providing a clarified fraction or a fraction for analysis of biological fluids and the like includes a disposable filtration vessel with a first reservoir chamber adapted to receive the fluid to be fractionated, a second reservoir chamber and a flow channel that extends between the reservoir chambers. The lower surface of the flow channel is defined by a microporous sheet membrane, and collection structure is disposed on the side of the membrane opposite the flow channel. Low gas pressure (less than ten psi) applied alternately to liquid surfaces in the reservoir chambers produced reciprocating flow of the fluid between the reservoir chambers in a wide thin stream through the flow channel with resulting collection of a fraction of the liquid material that passes through the membrane. A one-half milliliter volume of plasma from a two milliliter volume sample of blood is obtained with the system in less than one minute without any discernible hemolysis.

REFERENCES:
patent: 3211645 (1965-10-01), Ferrari
patent: 3489145 (1970-01-01), Judson et al.
patent: 3556302 (1971-01-01), Agranat
patent: 3567031 (1971-03-01), Loeffler
patent: 3705100 (1972-12-01), Blatt et al.
patent: 4001117 (1977-01-01), Trechsel
patent: 4189385 (1980-02-01), Greenspan
patent: 4191182 (1980-03-01), Popovich et al.
patent: 4212742 (1980-07-01), Solomon et al.

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