Biological glue based on thrombin-conjugated nanoparticles

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

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C424S094670

Reexamination Certificate

active

07550282

ABSTRACT:
Thrombin-conjugated nanoparticles, wherein said nanoparticles comprise one or more organic and/or inorganic compounds and process for preparing the same are provided. The thrombin-conjugated nanoparticles are suitable for use in the preparation of fibrin-based biological sealant.

REFERENCES:
patent: 5916596 (1999-06-01), Desai et al.
patent: 6552172 (2003-04-01), Marx et al.
patent: 7220401 (2007-05-01), Lanza et al.
patent: 2002/0119572 (2002-08-01), Jacobson et al.
patent: 2003/0045690 (2003-03-01), Marx et al.
patent: 2003/0138490 (2003-07-01), Hu et al.
patent: 2003/0219786 (2003-11-01), Hallahan et al.
patent: 99/62079 (1999-12-01), None
patent: 03/037248 (2003-05-01), None
International Search Report for PCT/IL03/00977 dated Aug. 9, 2004.
Brandriss et al. “Synthesis and Characterization of Self-Assembled Hydrophoic Monolayer Coatings on Silica Colloids”, American Chemical Society, 1993, reprinted from Langmuir, 1993, vol. 9, No. 5, pp. 1232-1240.
Melamed et al. “Poly(N-vinyl α-phenylalanine) Microspheres: Synthesis, Characterization, and Use for Immobilization and Microencapsulation”, Journal of Colloid and Interface Science, 241, pp. 357-365, 2001.
Horák et al. “Biologically Active Thrombin-Containing Hydrogels Based on Poly(2-hydroxyethyl methacrylate) for Endovascular Occlusion”, Polymers in Medicine, 1991, vol. XXI, No. 1-2, pp. 31-40.
Bamnolker et al. “Dispersion Polymerization of Styrene in Polar Solvents: Effect of Reaction Parameters on Micropshere Surface Composition and Surface Properties, Size and Size Distribution, and Molecular Weight”, Journal of Polymer Science: Part A: Polymer Chemistry, vol. 34, 1857-1871, 1996, John Wiley & Sons.
Parrado et al., “Immobilization-Stabilization of Kerase, a Serine Protease fromStreptomyces fradiae, by Covalent Attachment to Porous Glass”, Biosic. Biotech. Biochem., 59 (5), pp. 906-907, 1995.
Müller et al. “Intravenously Injected Particles: Surface Properties and Interaction with Blood Proteins—The Key Determining the Organ Distribution”, Scientific and Clinical Applications of Magnetic Carriers, Plenum Press, New York, 1997, pp. 135-148.
Bendikiene et al. “Stabilization of Serine Proteases by Immobilization”, Stability and Stabilization of Biocatalysts, 1998, Elsevier Science B.V., pp. 583-588.
Grüttner et al., “Preparation and Characterization of Magnetic Nanospheres for In Vivo Application”, Scientific and Clinical Applications of Magnetic Carriers, Plenum Press, New York, 1997, pp. 53-67.
Margel et al., “Synthesis, Characterization, and Use of New Solid and Hollow, Magnetic and Non-Magnetic, Organic-Inorganic Monodispersed Hybrid Microspheres”, Scientific and Clinical Applications of Magnetic Carriers, Plenum Press, New York, 1997, pp. 37-51.
Margel et al., “Functional Nanospheres: Synthesis and Biological Applications”, Recent Res. Devel. In Polymer Science, 1 (1997), pp. 51-78.
Sugitachi et al., “New Materials for Hemostasis”, Progress in Artificial Organs—1985, ISAO Press, Cleveland 1986, pp. 1020-1023.
Liu et al., “Gold Labeling of Thrombin and Ultrastructural Studies of Thrombin-Gold Conjugate Binding by Fibrin”, Analytical Biochemistry 147, 1985, pp. 49-56.
Stöber et al., “Controlled Growth of Monodisperse Silica Spheres in the Micron Size Range”, Journal of Colloid and Interface Science 26, 1968, pp. 62-69.
Per Wikstrom et al, “Gas Phase Silylation; A Rapid Method For Preparation of High-Performance Liquid Chromatography Supports”, Elsevier Science Publishers B.V., Journal of Chromatography, 455 (1988) 105-117.
Oliver Lowry et al, “Protein Measurement With the Folin Phenol Reagent”, J. Biol. Chem. 193, p. 265-275 (1951).

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