Biological detection based on differentially coupled...

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Structured visual or optical indicator – per se

Reexamination Certificate

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Details

C422S402000, C422S068100, C422S082050

Reexamination Certificate

active

07959873

ABSTRACT:
A biosensor is comprised of a free and a biofunctionalized recognition self-sensing nanocantilever, a dock adjacent to the ends of the nanocantilevers, and a gap between the nanocantilevers and dock. The self-sensing cantilevers each include a semiconductor piezoresistor defined in a pair of legs about which the cantilevers flex. A bias power or current is applied to the piezoresistor. The sensitivity of the cantilevers is optimized for a given ambient temperature and geometry of the cantilevers and dock by minimizing the force spectral density, SF, of the cantilevers to determine the optimum bias power, Pin. A sub-aN/√Hz force sensitivity is obtained by scaling down the dimensions of the cantilevers and supplying an optimum bias power as a function of temperature and geometry.

REFERENCES:
patent: 5780304 (1998-07-01), Matzinger
patent: 6016686 (2000-01-01), Thundat
patent: 6096559 (2000-08-01), Thundat et al.
patent: 6602469 (2003-08-01), Maus
patent: 6805839 (2004-10-01), Cunningham et al.
patent: 7560070 (2009-07-01), Baller et al.
patent: 2003/0027351 (2003-02-01), Manalis et al.

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