Biological cell treatment method and apparatus

Details Biological cell treatment method and apparatus Biological cell treatment method and apparatus

1991-08-08

1994-05-03

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

4352401, 4352402, 4352404, 435284, 435287, 435291, 435300, 435301, 935 89, 935 94, 935 98, 436 63, 436807, 436809, C12Q 102, C12N 500, C12M 100, C12M 120

Patent

active

053087577

ABSTRACT:
In determining the effectiveness of parameters on cells, after treatment of the cells with one or more selected parameters, the results of the treatment can be quickly determined by measuring the number n.sub.0 of cells having a predetermined cell form, subsequently mechanically stressing the cells for a sufficient period of time t to change the cell form substantially, thereafter again measuring the number n of cells having the predetermined cell form, and determining the cell viability .tau.defined by .tau.=t/1n(n.sub.0
).

REFERENCES:
patent: 4476225 (1984-10-01), Grigorian et al.
patent: 4729949 (1988-03-01), Weinreb
patent: 4760020 (1988-07-01), Neufeld
patent: 4894343 (1990-01-01), Tanaka et al.
patent: 4895805 (1990-01-01), Sato et al.
Sensors & Actuators, A21-A23, 1990, "Individual and Mass Operation of Biological Cells Using Micromechanical Silicon Devices", Sato et al, pp. 948-953.
Journal of Japan Society for Precision Engineering, 56, 1990, "Development of One-to-One Biological Cell Fusion Technique Using Micromechanical Devices", Kawamura et al, pp. 86-91.

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