Chemistry: analytical and immunological testing – Process or composition for determination of physical state... – Corrosion resistance or power
Reexamination Certificate
2005-02-15
2005-02-15
Chin, Christopher L. (Department: 1641)
Chemistry: analytical and immunological testing
Process or composition for determination of physical state...
Corrosion resistance or power
C424S009320, C424S009340, C424S009341, C424S009360, C428S402000, C428S402240, C428S403000, C428S404000, C428S405000, C428S406000, C436S172000, C436S173000, C436S523000, C436S524000, C436S525000, C436S527000
Reexamination Certificate
active
06855551
ABSTRACT:
The present invention provides a composition comprising fluorescent semiconductor nanocrystals associated to a compound, wherein the nanocrystals have a characteristic spectral emission, wherein said spectral emission is tunable to a desired wavelength by controlling the size of the nanocrystal, and wherein said emission provides information about a biological state or event.
REFERENCES:
patent: 5293050 (1994-03-01), Chapple-Sokol et al.
patent: 5354707 (1994-10-01), Chapple-Sokol et al.
patent: 5422489 (1995-06-01), Bhargava
patent: 5505928 (1996-04-01), Alivisatos et al.
patent: 5525377 (1996-06-01), Gallagher et al.
patent: 5751018 (1998-05-01), Alivisatos et al.
patent: 5985353 (1999-11-01), Lawton et al.
patent: 5990479 (1999-11-01), Weiss et al.
patent: 6423551 (2002-07-01), Weiss et al.
patent: WO 9804740 (1998-02-01), None
patent: 9819963 (1998-05-01), None
patent: WO 9833070 (1998-07-01), None
Matsumoto et al. (1996). Preparation of monodisperse CdS Nanocrystal by size selective Photocorrosion. J. Phys. Chem. 100(32):13781-13785.
Dabbousi et al. (1997). (CdSe)ZnS core-shell quantum-dots: synthesis and characterization of a size series of highly luminescent nanocrystal. J. Phys. Chem. B. 101:9463-9475.
Coffer et al. (1992). Characterization of quantum confined CdS nanocrystallites stabilized by deoxyribonucleic Acid (DNA). Nanotechnology. 3:69-76.
Mahtab et al. (1995). Protein-sized quantum dot luminescence can distinguish between “straight”, “bent”, and “kinked” oligonucletides. J. Am. Chem. Soc. 117:9099-9100.
Nirmal et al. (1996), Fluorescence intermittency in single cadmium selenide nanocrystals. Nature. 383:802-804.
Bawendi et al. (1992) Luminescence properties of CdSe quantum crystallites: resonance between interior and surface localized states. J. Chem. Phys. 96(2):946-954.
Correa-Duarte et al. (1998). Stabilization of CdS semiconductor nanoparticles against photodegradation by silica coating procedure. Chem. Phys. Lett. 286:497-501.
Norris et al. (1996). Measurement and assignment of the size-dependent optical spectrum in CdSe quantum dots. Physical Review B. 53(24):16338-16346.
Norris et al. (1996). Size dependence of exciton fine structure in CdSe quantum dots. Physical Review B, 53(24): 16347-16354.
Hines et al. (1996). Synthesis and characterization of strongly luminescing ZnS-Capped CdSe nanocrystals. J. Phys. Chem. 100:468-471.
Mahtab et al. (1996 Preferential adsorption of a “kinked” DNA to a neutral curved surface: comparisons to and implications for nonspecific DNA-protein interactions. J. Am. Chem Soc. 118:7028-7032.
Murphy et al. (1997) Quantum dots as inorganic DNA-binding proteins. Mat. Res. Soc. Symp. 452:597-600.
Lawless et al. (1995). Bifunctional capping of CdS nanoparticles and bridging to TiO2. J. Phys. Chem. 99:10329-10335.
Alivisatos (1996). Perspective on the physical chemistry of semiconductor nanocrystals. J. Phys. Chem. 100: 13226-13239.
Spanhel, et al., “Photochemistry of Colloidal Semiconductors. Surface Modification and Stability of Strong Luminescing CdS Particles,”J. Am. Chem. Soc.109(19):5649-5655, 1987.
Kortan, et al., “Nucleation of Growth of CdSe on ZnS Quantum Crystallite Seeds, and Vice Versa, in Inverse Micelle Media,”J. Am. Chem. Soc.112:1327-1332, 1990.
Coffer, et al., “Characterization of quantum-confined CdS Nanocrystallites stabilized by deoxyribonucleic acid (DNA),”Nanotechnology3:69-76, 1992.
Murray, et al., “Synthesis and Characterization of Nearly Monodisperse CdE (E=S, Se, Te) Semiconductor Nanocrystallites,”J. Am. Chem. Soc.115(19):8706-8715, 1993.
Whitesell, et al., “Directionally Aligned Helical Peptides on Surfaces,”Science261:73-76, Jul. 1993.
Rajh, et al., “Synthesis and Characterization of Surface-Modified Colloidal CdTe Quantum Dots,”J. Phys. Chem.97:11999-12003, Nov. 1993.
Colvin, et al., “Light-emitting diodes made from cadmium selenide nanocrystals and a semiconducting polymer,”Nature370(6488):354-357, Aug. 4, 1994.
Lawless, et al., “Bifunctional Capping of CdS Nanoparticles and Bridging to TiO2,”J. Phys. Chem.99:10329-10335, 1995.
Dabbousi, et al., “Electroluminescence from CdSe quantum-dot/polymer composites,”Appl. Phys. Lett.66(11):1316-1318, Mar. 13, 1995.
Alivisatos, “Perspectives on the Physical Chemistry of Semiconductor Nanocrystals,”J. Phys. Chem.1996(100):13226-13239, 1996.
Danek, et al., “Synthesis of Luminescent Thin-Film CdSe/ZnSe Quantum Dot Composites Using CdSe Quantum Dots Passivated with an Overlayer of ZnSe,”Chem. Mater.8(1):173-180, 1996.
Liz-Marzan, et al., “Synthesis of Nanosized Gold-Silica Core-Shell Particles,”Langmuir12:4329-4335, 1996.
Matsumoto, et al., “Preparation of Monodisperse CdS Nanocrystals by Size Selection Photocorrosion,”J. Phys. Chem100(32):13781-13785, 1996.
Rogach, et al., “Synthesis and Characterization of Thiol-Stabilized CdTe Nanocrystals,”Ber. Bunsenges. Phys. Chem.100(11):1772-2778, 1996.
Hines, et al., “Synthesis and Characterization of Strongly Luminescing ZnS-Capped CdSe Nanocrystals,”J. Phys. Chem.100:468-471, Jan. 1996.
McGall, et al., “Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists,”Proc. Natl. Acad. Sci. USA93:13555-13560, Nov. 1996.
Chee, et al., “Accessing Genetic Information with High-Density DNA Arrays,”Science274(5287):610-614, Oct. 25, 1996.
Empedocles, et al., “Photoluminescence Spectroscopy of Single CdSe Nanocrystallite Quantum Dots,”Phys. Rev. Lett.77(18):3873-3876, Oct. 1996.
Nirmal, et al., “Fluorescence Intermittency in single Cadmium Selenide Nanocrystals,”Nature383:802-804, Oct. 1996.
Egner, et al., “Tagging in combinatorial chemistry: the use of coloured and fluorescent beads,”Chem. Commun.:735-736, 1997.
Gan, et al., “Enhanced Photoluminescence and Characterization of Mn-Doped ZnS Nanocrystallites Synthesized in Microemulsion,”Langmuir1997 (13):6427-6431, 1997.
Empedocles, et al., “Quantum-Confined Stark Effect in Single CdSe Nanocrystallite Quantum Dots,”Science278:2114-2117, Dec. 1997.
Fodor, “Techwire,”Science277(5324):393-395, Jul. 18, 1997.
Kuno, et al., “The band edge luminescence of surface modified CdSe nanocrystallites: Probing the luminescing state,”J. Chem. Phys.106(23):9869-9882, Jun. 1997.
Dabbousi, et al., “(CdSe)ZnS core-shell quantum dots: synthesis and characterization of a size series of highly luminescent nanocrystallites,”J. of Phys. Chem. B101(46):9463-9475, Nov. 13, 1997.
Guha, et al., “Hybrid organic-inorganic semiconductor-based light-emitting diodes,”J. Appl. Phys.82(8):4126-4128, Oct. 15, 1997.
Fox, et al., “Fluorescence and Redox Activity of Probes Anchored through an Aminotrithiol to Polycrystalline Gold,”Langmuir14:816-820, 1998.
Mikulec, et al., “Fluorescent semiconductor nanocrystallites derivatized with biomolecules,”Amer. Chem. Soc. Nat'l Meeting,Boston, MA, Aug. 24, 1998.
Service, “Semiconductor Beacons Light Up Cell Structures,”Science281:1930-1931, Sep. 25, 1998.
Jacoby, “Quantum dots meet biomolecules,”C&E News:8, Sep. 28, 1998.
Bruchez, et al., “Semiconductor Nanocrystals as Fluorescent Biological Labels,”Science281:2013-2016, Sep. 1998.
Chan, et al., “Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection,”Science281:2016-2018, Sep. 1998.
Lett, “Color-Coding Quantum Dots Debut With Promising Careers In Clinical Diagnostics Field,” :1-2, Sep. 25, 1998.
Bawendi Moungi G.
Mikulec Frederic V.
Sundar Vikram C.
Chin Christopher L.
Massachusetts Institute of Technology
Steptoe & Johnson LLP
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