Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1993-06-03
1996-08-27
Azpuru, Carlos
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
514 2, 514 12, 514 21, 514955, 530835, 530840, 530841, 530842, 530846, 530850, A61F 202, A61K 3843, A61K 3850
Patent
active
055499040
ABSTRACT:
A formulated biological adhesive composition utilizes tissue transglutaminase in a pharmaceutically acceptable aqueous carrier. The tissue transglutaminase is used in an effective catalytic amount to promote adhesion between tissue surfaces upon treatment thereof by catalyzing the reaction between glutaminyl residues and amine donors of the tissue and/or the enzyme. The carrier contains a divalent metal ion such as calcium to promote said reaction.
REFERENCES:
patent: 4325867 (1982-04-01), Eberle et al.
patent: 4582794 (1986-04-01), Russell
patent: 4728643 (1988-03-01), Holick et al.
patent: 4968713 (1990-11-01), Baldwin et al.
patent: 5037816 (1991-08-01), Holick et al.
patent: 5270300 (1993-12-01), Hunziker
Taylor, D. A. et al., "Novel Transglutaminases for Tissue Glues," Clinical Research, vol. 40, No. 01, 1992, p. 31A.
D. Aeschlimann and M. Paulsson, "Transglutaminases: Protein Cross-Linking Enzymes in Tissues and Body Fluids", Thrombosis and Hemostasis, vol. 71, pp. 402-415 (1994).
T. Kanaji, et al., "Primary Structure of Microbial Transglutaminase from Streptoverticillium sp. Strain s-8112", J. of Biol. Chem., 268:11565-11572 (1993).
J. E. Folk and D. I. Chung, "Molecular and Catalytic Properties of Transglutaminases", Adv. Enzymol. , 109-110 and Chapter D., Role of Metal Ions, pp. 133-141 (1973).
Aeschlimann, D. et al: "Cross-Linking of Laminin-Nidogen Complexes . . . " J. Biol Chem 266:15308-15317 (1991).
Arnoczky, S. P. et al: "Microvasculature of the Human Meniscus" Am J Sports Med 10(2):90-95 (1982).
Bauer, M. et al: "Chondral Lesions of the Femoral Condyles . . . " Arthroscopy 4(2):97-102 (1988).
Buckwalter, J. A. et al: "Articular Cartilage: Composition, Structure . . . " reprinted in Articular Cartilage & Knee Joint Function: Basic Science and Arthroscopy, New York, Raven Press (1990).
Carrell, N. A. et al: "Electron Microscopy and Hydrodynamic Properties . . . " J Biol Chem 264(1):551-556 (1989).
Connellan, J. M. et al: "Structural Properties of Guinea Pig Liver . . . " J. Biol Chem 246(4):1093-1098 (1971).
Coutts, R. D., et al: "Rib periochondrial Autografts in Full-Thickness . . . " Chip Orthop 263-273 (1992).
Federico, D. J. et al: "Osteochondritis Dissecans of the Knee: A Historical Review of Etiology & Treatment," Arthroscopy 6(3):190-197 (1990).
Folk, J. E. et al; "The .epsilon.-(.gamma.-Glutamyl)Lysine Crosslink and the Catalytic Role of Transglutaminases," Adv Protein Chem 31:1-133 (1977).
Folk, J. E.: "Transglutaminases," Ann Rev Biochem 49:517-531 (1980).
Gorman, J. J. et al.: "Structural Features of Glutamine Substrates for Transglutaminases," J Biol Chem 25(14):9007-9010 (1984).
Greenberg, C. S. et al.: "Transglutaminases: Multifunctional Cross-Linking Enzymes That Stabilize Tissues," FASEB J5:3071-3077 (1991).
Hauschka, P. V. et al: Growth Factors in Bone Matrix: "Isolation of Multiple Types by Affinity . . . " J Biol Chem 261(27):12665-12674 (1986).
Homminga, G. N. et al.: "Perichondral Grafting for Cartilage Lesions of the Knee," J Bone Joint Surg (Br) 72-B(6):1003-1007 (1990).
Homminga, G. N. et al.: "Repair of Articular Defects by Perichondrial Grafts: Experiments in the Rabbit," Acta Orthop Scand 60(3):326-329 (1989).
Bowness, J. M. et al: "Identification of a Substrate Site for Liver Transglutaminase . . . " J Biol Chem 262(3):1022-1024 (1987).
Ichinose, A. et al.: "Structure of Transglutaminases," J Biol Chem 265(23):13411-13414 (1990).
Ikura, K. et al.: "Amino Acid Sequence of Guinea Pig Liver Transglutaminase From Its cDNA Sequence," Biochemistry 27:2898-2905 (1988).
Itay, S. et al.: "Use of Cultured Embryonal Chick Epiphyseal Chondrocytes as Grafts for Defects in Chick Articular Cartilage," Clin Orthop 220:284-303 (1987).
Jurgensen, K. et al.: "Adhesion Between Cartilage Tissue Surfaces, Connective Tissue Surfaces . . . " M. E. Muller-Institute for Biomechanics, 1-20 (1992).
Mitchell, N. et al.: "Effect of Patellar Shaving in the Rabbit," J Orthop Res 5:388-392 (1987).
Mitchell, N. et al.: "Healing of Articular Cartilage in Intra-Articular Fractures in Rabbits," J Bone and Joint Surg 62-A:628-634 (1980).
Mitchell, N. et al.: "The Resurfacing of Adult Rabbit Articular Cartilage By Multiple Perforations . . . " J. Bone and Joint Surg 58-A:230-233 (1976).
Mitchell, N. et al.: "Effect of Patellar Shaving in the Rabbit, " J Orthop Res 5:388-392 (1987).
Mitchell, N. et al.: "Healing of Articular Cartilage in Intra-Articular Fractures in Rabbitts," J Bone and Joint Surg 62-A:628-634 (1980).
Mitchell, N. et al.: "The Resurfacing of Adult Rabbit Articular Cartilage By Multiple Perforations . . . " J Bone and Joint Surg 58-A:230-233 (1976).
Mow, V. C. et al: "Cartilage and Diarthrodial Joints as Paradigms for Hierarchical Materials and Structures," Biomaterials 13(2):67-97 (1992).
Lorand, L. et al: "Transglutaminases," Mol Cell Biochem 58:9-35 (1984).
O'Driscoll, S. W. et al.: "Durability of Regenerated Articular Cartilage Produced by Free Autogenous Periosteal . . . " J Bone & Joint Surg 70-A(4):595-606 (1988).
Pineda, S. J. et al.: "Osteochondral Progenitor Cells Enhance Repair of Large Defects in Rabbit Articular Cartilage," Trans Orthop Res Soc 17(2):598 )1992).
Pridie, K. H.: "A Method of Resurfacing Osteoarthritic Knee Joints," J Bone Joint Surg (Br) 41-B:618-619 (1959).
Schmid, A. et al.: "Results After Cartilage Shaving Studied By Electron Microscopy," Am J Sports Med 15(4);386-387 (1987).
Scott, D. J. et al: "Osteochondritis Dissecans of the Knee in Adults," Clin Orthop 76:82-86 (1990).
Scott, W. N. et al.: "Injuries of the Knee," reprinted in Rockwood and Green's Fractures in Adults, Philadelphia, J. B. Lippincott Company (1991).
Seyedin, S. M. et al.: "Cartilage-Inducing Factor-.alpha.: Apparent Identify to Transforming Growth . . . " J Biol Chem 261(13):5693-5695 (1986).
Zapf, J. et al.: "Insulin-Like Growth Factors/Somatomedins: Structure, Secretion, Biological Actions . . . " Horm Res 24:121-130 (1986).
Aeschlimann, D. et al: "Expression of Tissue Transflutaminase in Skeletal Tissues Correlates with Events of Terminal Differentiation of Chondrocytes" J. Cell Biol. vol. 120[6], p.1461 to 1470 (1993).
Gorman, J. J. et al: "Structural Features of Glutamine Substrates for Transfutaminases" J. Biol Chem 256(6): 2715(1981).
Carney, S. L. "Proteoglycans. Carbohydriate Analysis" Oxford, IRL Press (1986).
Schlag, G. et al (Ids) "Fibrin Sealant in Operative Medicine", Traumatology Orthopaedics vol. 7, Sprize Veslag, New York, 1986.
Smilie, I. "Osteochrondritis Dissecans", London, Livingston (1960).
Aeschlimann Daniel
Hunziker Ernst B.
Juergensen Kay
Azpuru Carlos
Orthogene, Inc.
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