Biologic response modifier

Details Biologic response modifier Biologic response modifier

1987-06-02

1990-11-20

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 43, 424 11, 424 852, 424 87, 4284022, 436829, 514885, A61K 927, A61K 4505, B01J 1302

Patent

active

049718010

ABSTRACT:
A biologic response modifier is described for human or animal treatment. It comprises natural membrane vesicles and ribosomes in a suspending buffer. The membrane vesicles are comprised of cellular membrane material endogenous to a selected microorganism. The ribosomes are also endogenous to the selected microorganism. The biologic response modifier is substantially free of endotoxin, intact cells, cell walls, and cell membrane fragments. The selected microorganism is one which does not evoke a significant immune deviating response in the patient and is an organism which is substantially non-pathogenic in humans. The selected microorganism is also one in which membrane vesicles are capable of being formed from cell membrane material and which are readily endocytosed by the monocyte-macrophage cell line of the patient.

REFERENCES:
patent: 4053585 (1977-10-01), Allison et al.
patent: 4241046 (1980-12-01), Papahadjopoulos et al.
patent: 4323561 (1982-04-01), Nowotny
patent: 4372949 (1983-02-01), Kodama et al.
Bergman et al., "New Test for Endotoxin Potency Based Upon Histamine Sensitization in Mice", Infection and Immunity, vol. 18, No. 2, Nov. 1977, pp. 352-355.
U.S. Ser. No. 259,742 filed May 1, 1981, Urban, et al.
West et al., "Natural Cytotoxic Reacivity of Human Lymphocytes Against a Myeloid Cell Line: Characterization of Effector Cells", The Journal of Immunology, vol. 118, No. 1, Jan. 1977, pp. 355-361.

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