Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1995-06-02
1997-03-04
Kishore, Gollamud S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424422, 424424, 424426, 424484, A61K 9127
Patent
active
056076940
ABSTRACT:
The present invention describes a biologically compatible bioadhesive sealant composition comprising fibrin glue and liposomes for use in mammals, including humans. Fibrin glue of the invention comprises fibrinogen and thrombin which are mixed together in various modes with liposomes and applied to a site of injury, to a wound, or to a surgical or nonsurgical incision or opening. In accordance with the invention, the liposomes are embedded within the fibrin glue after coagulation has occurred, and may release bioactive substances contained within their aqueous interiors to promote healing and protection during the recovery process. The bioadhesive composition of the invention promises to maintain hemostasis after surgeries and improves upon existing glues or gel formulations due to its complete biological compatibility, its formation in situ, and its provision of bioactive therapeutics via entrapped liposomes directly to the site. Long-lasting biophysical and biomechanical properties as well as therapeutic value are imparted to the fibrin glue components by the liposome component of the composition. The biocompatible fibrin glue and liposome composition is also amenable for fabrication into films, coatings, or membranes for in vitro and in vivo uses.
REFERENCES:
patent: 4224179 (1980-09-01), Schneider
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4708861 (1987-11-01), Popmacu et al.
patent: 5206023 (1993-04-01), Hunziker
patent: 5209776 (1993-05-01), Bass et al.
patent: 5290552 (1994-03-01), Sierra
G. Posts, 1980, "The Interaction of Lipid Vesicles (Liposomes) with Cultured Cells and their use as Carriers for Drugs and Macromolecules", In: Lipsomes in Biological Systems, Eds. G. Gregoriadis and A. C. Allison, John Wiley and Sons, Ltd., pp. 101-151.
D. Goren et al., 1990, "The Influence of Physical Characteristics of Liposomes Containing Doxorubioin on their Pharmacological Behavior", Biochem. Biophys. Acta., 1029:285-294.
C. Pidgeon and C. A. Hunt, 1987, "Photolabile liposomes as Carriers", Meths. Enzymol., 149(13):99-111.
S. Perretz et al., 1991, "A Simple Method for the Preparation of Liposomes for Pharmaceutical Applications: Characterization of the Liposomes", J. Pharm. Pharmacol., 43:154-161.
S. S. Davis and I. M. Walker, 1987, "Multiple Emulsions as Targetable Delivery Systems", Meths. Enzymol., 149:1-87.
F. Szoka, Jr. and D. Papahadjopoulos, 1980, "Comparative Properties and Methods of Preparation of Lipid Vesicles (Liposomes)", Ann. Rev. Biophys. Bioeng. 9:467-508.
V. P. Torohilin et al., 1978, "Comparative Studies on Covalent and Noncovalent Immobilization of Protein Molecules on the Surface of Liposomes", Biochem. Biophys. Res. Commun. 85 (3):983-990.
G. Firth, 1984, "Studies on the Intracerebral Injection of Blaomyclin Free and Entrapped Within Liposomes in the Rat", J. Neutrol. Neurosug. Psychiat., 47:585-589.
Kishore Gollamud S.
New York Blood Center Inc.
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