Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2009-10-08
2010-12-14
Graser, Jennifer E (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S185100, C424S234100
Reexamination Certificate
active
07850974
ABSTRACT:
A bioinformatic method for identifying and isolating proteins and peptides with MSCRAMM®-like characteristics from Gram positive bacteria, such asEnterococcus, Staphylococcus, StreptococcusandBacillusbacteria, and proteins and peptides obtained thereby are provided which can be utilized in methods to prevent and treat infections caused by Gram-positive bacteria. The method involves identifying from sequence information those proteins with a putative C-terminal LPXTG (SEQ ID NO:1) cell wall sorting signal and other structural similarities to MSCRAMM® proteins having the LPXTG-anchored cell wall proteins. The MSCRAMM® proteins and immunogenic regions therein that are identified and isolated using the present invention may be useful in the diagnosis, treatment or prevention of Gram positive bacterial infections.
REFERENCES:
patent: 6617156 (2003-09-01), Doucette-Stamm et al.
Murphy et al. Pediatr. Infect. Dis. J. 1989. 8: S66-S68.
Yamanaka et al (J. Pediatrics. 1993. 122(2): 212-218).
Bowden Maria G.
Hall Andrea
Hook Magnus
Hutchins Jeff T.
Patti Joseph M.
Graser Jennifer E
Inhibitex, Inc.
Schulman B. Aaron
Stites & Harbison PLLC
The Texas A&M University System
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