Liquid purification or separation – Processes – Chromatography
Patent
1988-11-18
1991-04-30
Fisher, Richard V.
Liquid purification or separation
Processes
Chromatography
210635, 2101982, 436111, 436161, 436816, 436901, B01D 1508
Patent
active
050116088
ABSTRACT:
A method for assaying compounds belonging to the group biogenic amines and including catecholamines, indoleamines, their metabolites and derivatives, and other small molecular weight compounds using a boric acid extraction method followed by high pressure liquid chromatographic separation in conjunction with electrochemical detection. The method utilizes high purity chemical and liquid components, a microparticulate-silica bonded phenyl stationary phase in the chromatography column and special cleaning and maintenance measures for the various components of the assaying apparatus which result in reduced baseline noise and allow the electrochemical cell to be operated at a sensitivity of one nanoamp or less full scale deflection on a continuous basis.
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Fisher Richard V.
McCarthy Neil M.
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