Bioflavonoids as plasma high density lipoprotein level increasin

Details Bioflavonoids as plasma high density lipoprotein level increasin Bioflavonoids as plasma high density lipoprotein level increasin

1998-10-22

2000-10-17

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514456, 4241951, A61K 3170

Patent

active

061332410

ABSTRACT:
A method for increasing the plasma high density lipoprotein(HDL) level in a mammal comprises administering a bioflavonoid of formula(I) or plant extract containing same thereto: ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5.sub.7 R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are each independently hydrogen; a hydroxy group; a C.sub.1-9 alkoxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C.sub.1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.5-9 cycloalkyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.5-9 cycloalkylcarbonyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.2-10 or C.sub.16-18 acyloxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C.sub.1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen and nitro group; a rutinosyl group; or a rhaminosyl group; and

REFERENCES:
patent: 3876777 (1975-04-01), Horowitz et al.
patent: 4496548 (1985-01-01), Moldowan et al.
patent: 5763414 (1998-06-01), Bok et al.

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