Bioerodible system for delivering drug manufactured from poly(ca

Details Bioerodible system for delivering drug manufactured from poly(ca Bioerodible system for delivering drug manufactured from poly(ca

1979-07-05

1981-02-10

Michell, Robert W.

Surgery

Respiratory method or device

Ozone or ion generation

128271, 424 33, A61M 700

Patent

active

042495318

ABSTRACT:
A device for the controlled continuous administration of an active agent to an environment of use is disclosed. The device comprises a body of erodible agent release rate controlling material containing an agent dispersed therethrough; the rate controlling material is a hydrophobic poly(carboxylic acid) having one ionizable carboxylic hydrogen for each 8 to 12 carbon atoms, which material erodes at a controlled and continuous rate over a prolonged period of time in response to the environment by a process of carboxylic hydrogen ionization, thereby releasing the dispersed agent at a controlled rate over a prolonged period of time.

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Lappas, L. et al., J. Pharm. Sci., vol. 56, pp. 1257-1261, 1967.
Heyd, A. et al., J. Pharm. Sci., vol. 58, No. 5, pp. 586-588, 1969; vol. 59, No. 7, pp. 947-949, 1970.

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