Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1989-08-28
1991-07-09
Nielsen, Earl
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424423, 424457, 514179, 528425, C08G 6534, A61K 914
Patent
active
050304577
ABSTRACT:
Bioerodible ortho ester polymers useful for preparing soft form bioerodible pharmaceutical compositions such as ointments, creams, gels and the like are provided. A novel synthetic method for preparing the polymers is provided as well. Synthesis involves a one-step reaction between a monomeric ortho ester and a triol. The pharmaceutical compositions of the invention are useful for the controlled release of therapeutic agents, and may be administered for a variety of purposes, such as for the treatment of deep wounds, including burns, and for the treatment of periodontal disease.
REFERENCES:
patent: 4066747 (1978-01-01), Capozza
patent: 4079038 (1978-03-01), Choi et al.
patent: 4119579 (1978-10-01), Capozza
patent: 4304767 (1981-12-01), Heller et al.
patent: 4405798 (1983-09-01), Hall et al.
patent: 4549010 (1985-10-01), Sparer et al.
Burt, et al., J. Amer. Chem. Soc. (1982) 104:3687-3690.
Padias, et al., Macromolecules (1982) 15(2):217-223.
Padias, et al., "Synthesis and Polymerization of Atom-Bridged Bicyclic Acetals and Orthoesters: A New Mechanism," pp. 258-259.
Padias, et al., "Ring-Opening Polymerization," Chapter 23, pp. 314-333, ACS Symposium Series 286, American Chem. Soc., Washington, D.C. (1985).
Szymanski, et al., J. Polymer Science: Polymer Letters Edition (1983) 21:177-187.
Heller Jorge
Ng Steve Y. W.
Nielsen Earl
Pharmaceutical Delivery Systems, Inc.
Reed Dianne E.
LandOfFree
Bioerodible polymers useful for the controlled release of therap does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bioerodible polymers useful for the controlled release of therap, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioerodible polymers useful for the controlled release of therap will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-617129