Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1986-01-21
1990-01-02
Teskin, Robin
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424427, 424 78, 424409, 424420, 528271, 528206, 528207, 524 17, 524 21, 524599, A61M 3100, A61F 546, A61K 3178
Patent
active
048912255
ABSTRACT:
A novel hydrophobic polymeric matrix is provided which is suitable for use after implantation in vivo in a subject for the controlled release and delivery of biologically active substances such as drugs, antibiotics, steroids and the like. Alternatively, the matrix can be used outside the body for release of fragrances, pesticides and the like. The implantable matrix comprises a polymeric polyanhydride formulation whose internal anhydride linkages are hydrolytic in nature in varying degrees in accordance with the chemical composition of the backbone, pH and temperature of the environment. As the individual anhydride linkages become hydrolyzed, the matrix erodes predominantly by surface erosion into non-toxic biocompatible degradation products with concomitant release of the biologically active substance.
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Rosen
Langer Robert S.
Rosen Howard
Massachusetts Institute of Technology
Teskin Robin
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