Bioerodible devices and compositions for diffusional release of

Details Bioerodible devices and compositions for diffusional release of Bioerodible devices and compositions for diffusional release of

1994-01-21

1996-08-06

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424426, 424428, 424444, 424486, 424499, 424501, 424468, A61K 910, A61K 914, A61K 922, A61K 970

Patent

active

055431569

ABSTRACT:
The present invention is directed to erodible delivery devices and to the compositions comprising the devices. The devices comprise (a) a body formed of a bioerodible polymer or polymers together with a required excipient not generally considered to be a pore-former ("required excipient"), and (b) an active agent. The agent is released from the device at a controlled rate and in a therapeutically effective amount, with the rate being primarily independent of the erosion rate of the polymer. The rate of release of the active agent from the polymeric compositions of the present invention is significantly increased over the rate of release dependent on erosion of the polymer matrix. The invention makes possible the increased control over and improved reproducibility of the release profile of the agent from the polymer.
The invention is further directed to a method of delivering to an environment of use an active agent, which method comprises placing an appropriately sized and shaped delivery device of the above description in the environment of use.

REFERENCES:
patent: 4070347 (1978-01-01), Schmitt
patent: 4093709 (1978-06-01), Choi et al.
patent: 4122158 (1978-10-01), Schmitt
patent: 4131648 (1978-12-01), Choi et al.
patent: 4138344 (1979-02-01), Choi et al.
patent: 4155992 (1979-05-01), Schmitt
patent: 4180646 (1979-12-01), Choi et al.
patent: 4432964 (1984-02-01), Shell et al.
Plastic Encyclopedia, vol. 46, pp. 62 to 70 (1969).

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