Bioerodable sustained release implants

Details Bioerodable sustained release implants Bioerodable sustained release implants

1989-01-23

1990-12-04

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424422, 424424, 424425, 424426, 424486, A61K 900

Patent

active

049752804

ABSTRACT:
A device for controlled release of one or more pharmacologically active substances within an animal which comprises (i) a body of a bioerodable solid state poly(amino acid ester) phosphazene polymer, and (ii) at least one pharmacologically active substance physically incorporated within said body. The device may comprise an implantable body in which the poly(amino acid ester)phosphazene polymer is a matrix within which such pharmacologically active substance is dispersed. Alternatively, the polymer may constitute a coating or container within which such pharmacologically active substance is physically encased--i.e., the polymer surrounds the active agent as in a capsule or in a microencapsulated form. Results of in vivo experiments using implants of poly[bis((ethyl glycino)phosphazene] containing 25% ethidium are described.

REFERENCES:
patent: 4249531 (1981-02-01), Heller et al.
patent: 4347234 (1982-08-01), Wahlig et al.
patent: 4351337 (1982-09-01), Sidman
patent: 4638045 (1987-01-01), Kohn et al.
patent: 4639366 (1987-01-01), Heller

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