Bioerodable polymeric adhesives for tissue repair

Details Bioerodable polymeric adhesives for tissue repair Bioerodable polymeric adhesives for tissue repair

2006-10-17

2006-10-17

Webman, Edward J. (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C424S426000

Reexamination Certificate

active

07122205

ABSTRACT:
Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.

REFERENCES:
patent: 4157418 (1979-06-01), Heilmann
patent: 4172934 (1979-10-01), Heilmann
patent: 4243775 (1981-01-01), Rosensaft et al.
patent: 4347234 (1982-08-01), Wahlig et al.
patent: 4424208 (1984-01-01), Wallace et al.
patent: 4438198 (1984-03-01), Schmer
patent: 4440750 (1984-04-01), Glowacki et al.
patent: 4595713 (1986-06-01), St. John
patent: 4637905 (1987-01-01), Gardner
patent: 4645503 (1987-02-01), Lin et al.
patent: 4694103 (1987-09-01), Krepski et al.
patent: 4757128 (1988-07-01), Domb et al.
patent: 4804691 (1989-02-01), English et al.
patent: 4843112 (1989-06-01), Gerhart et al.
patent: 4888176 (1989-12-01), Langer et al.
patent: 4888413 (1989-12-01), Domb
patent: 4902508 (1990-02-01), Badylak et al.
patent: 4906474 (1990-03-01), Langer et al.
patent: 4956178 (1990-09-01), Badylak et al.
patent: 5019379 (1991-05-01), Domb et al.
patent: 5075115 (1991-12-01), Brine
patent: 5085861 (1992-02-01), Gerhart et al.
patent: 5133755 (1992-07-01), Brekke
patent: 5171579 (1992-12-01), Ron et al.
patent: 5206341 (1993-04-01), Ibay et al.
patent: 5286763 (1994-02-01), Gerhart et al.
patent: 5366508 (1994-11-01), Brekke
patent: 5464929 (1995-11-01), Bezwada et al.
patent: 5475063 (1995-12-01), Kaplan et al.
patent: 5679723 (1997-10-01), Cooper et al.
patent: 5824333 (1998-10-01), Scopelianos et al.
patent: 92111732.1 (1993-01-01), None
patent: 3-45265 (1991-02-01), None
J. Brandrup et al., “Polymer Handbook”, Fourth Edition,A Wiley-Interscience Publication, John Wiley&Sons, Inc., 1999, 6 pgs.
Webpage obtained through http://www.psrc.usm.edu/macrog/pet.htm, “Polyesters”, Printed on Jan. 15, 2003, 4 pgs.
Anderson, James M. et al.,Poly-α-Amino Acids as Biomedical Polymers, Biocompatibility of Tissue Analogs, vol. 1, Chapter 4, pp. 67-88 (1985).
Ferguson, David et al.,Bovine Bone Morphogenetic Protein(bBMP)Fraction-induced Repair of Craniotomy Defects in the Rhesus Monkey(Macaca speciosa), Clinical Orthopaedics and Related Research, No. 219, p. 251-258, Jun. 1987.
Ford, James et al.,Pharmaceutical Thermal Analysis, Ellis Howard Books in Biological Science, Chapter 2, John Wiley &Sons, New York (1989).
Gerhart, T.N. et al.,Antibiotic Release From an Experimental Biodegradable Bone Cement, Journal of Orthopaedic Research, 6:585-592, 1988.
Hollinger, Jeffrey O. et al.,Biodegradable Bone Repair Materials, Clinical Orthopaedics and Related Research, No. 207, pp. 290-305, (Jun., 1986).
Hollinger, Jeffrey,Factors for Osseous Repair and Delivery: Part II, J. Craniofac. Surg., 4 (3), pp. 135-141, (Jul. 1993).
Hollinger, Jeffrey O. et al.,Osseous Wound Healing with Xenogeneic Bone Implants with a Biodegradable Carrier, Surgery, vol. 107, No. 1, pp. 50-54, Jan. 1990.
Hotz, G. et al.,Bone Substitute With Osteoinductive Biomaterials-Current and Future Clinical Applications, Int. J. of Oral Maxillofacial Surgery, 23:413-417, 1994.
Kalb, Claudia et al.,Hope for Damaged Joints, Newsweek, p. 55, Jan. 29, 1996.
Kamegai, Akihide et al.,Bone Formation Under the Influence of Bone Morphogenetic Protein/Self-Setting Apatite Cement Composite as a Delivery System, Bio-Medical Materials and Engineering, vol. 4, No. 4, pp. 291-307, 1994.
Kenley, Richard A. et al.,Biotechnology and Bone Graft Substitutes, Pharmaceutical Research, vol. 10, No. 10, pp. 1393-1401, 1993.
Kohn, Joachim et al.,Polymerization Reactions Involving the Side Chains of α-L-Amino Acids, J. Am. Chem. Soc., 109 pp. 817-820, 1987.
Kulkarni, R.K. et al., Polylactic Acid for Surgical Implants, Arch Surg. vol. 93, pp. 839-843, Nov. 1966.
Kulkarni, R.K. et al.,Biodegradable Poly(lactic acid)Polymers, J. Biomed. Mater. Res., vol. 5 pp. 169-181, 1971.
Lane, Joseph M. et al.,Current Approaches to Experimental Bone Grafting, Orthop. Clin. North Am. 18(2), pp. 213-225, Apr. 1987.
Laurencin, C.T. et al.,Bioerodible Polyanhydrides for Antibiotic Drug Delivery: In Vivo Osteomyelitis Treatment in a Rat Model System, Journal of Orthopaedic Research, vol. 11, No. 2, pp. 256-262, 1993.
Leong, K. W. et al.,Bioerodible Polyanhydrides as Drug-Carrier Matrices. 1: Characterization, Degradation, and Release Characteristics, J. Biomed. Mater. Res., vol. 19, pp. 941-955, 1985.
Lindholm, T.S. et al.,Functional Carriers for Bone Morphogenetic Proteins, Annales Chirurgiae at Gynaecologiae, No. 82, pp. 3-12, 1993.
Lovell, T.P. et al.,Augmentation of Spinal Fusion with Bone Morphogenetic Protein in Dogs,Clinical Orthopaedics and Related Research, No. 243, pp. 266-274, Jun., 1989.
Miki, Takashi et al.,Effect of Freeze-Dried Poly-L-Lactic Acid Discs Mixed with Bone Morphogenetic Protein on the Healing of Rat Skull Defects, J. Oral. Maxillofac. Surg., No. 52, pp. 387-391, 1994.
Miyamoto, Shimpei et al.,Evaluation of Polylactic Acid Homopolymers as Carriers for Bone Morphogenetic Protein. Clinical Orthopaedics and Related Research, No. 278, pp. 274-285, May, 1992.
Miyamoto, Shimpei et al.,Polylactic Acid-Polyethylene Glycol Block Copolymer,Clinical Orthopaedics and Related Research, No. 294, pp. 333-343, Sep., 1993.
Miyamoto, S. et al.,Bone Induction and Bone Repair by Composites of Bone Morphogenetic Protein and Biodegradable Synthetic Polymers, Annales Chirurgiae et Gynaecologiae, No. 82, pp. 69-76, 1993.
Pinholt, Else Marie et al.,Bone Induction by Composites of Bioresorable Carriers and Demineralized Bone in Rats: A Comparative Study of Fibrin-Collagen Paste, Fibrin Sealant, and Polyorthoester With Gentamicin, J. Oral Maxillofac. Surg., 50:1300-1304, 1992.
Pulapura S. et al.,Biomaterials Based on “Pseudo”-Poly(Amino Acids): A Study of Tyrosine Derived Polyiminocarbonates, Polymer Preprints, vol. 31, No. 1, pp. 233-234, Apr. 1990.
Rokkanen, Pentti U.,Absorable Materials in Orthopaedic Surgery, Ann. Med., No. 23, pp. 109-115, 1991.
Sidman, K.R. et al.,Biodegradable, Implantable Sustained Release Systems Based on Glutamic Acid Copolymers, Journal of Membrane Science, vol. 7, No. 3, pp. 277-291, 1980.
Sigma Chemical Company :Biochemicals Organic Compounds and Diagnostic Reagents, pp. 1963-1965, (1996).
Storey, Robson F. et al.,Novel Synthesis of(Carboxylic Acid)-Telechelic Poly(∈-Caprolactone), Abstracts of Papers of the American Chemical Society, 1996, V.211, Mar. 24, p. 113-114.
Storey, Robson F. et al.,New Epoxy-Terminated Oligoesters: Precursors to Totally Biodegradable Networks, Journal of Polymer Science: Part A: Polymer Chemistry, vol. 31, pp. 1825-1838, 1993.
Stupp, Samuel I. et al.,Organoapatites: Materials for Artificial Bone. I. Synthesis and Microstructure, Journal of Biomedical Materials Research, vol. 26, 169-183, 1992.
Stupp, Samuel I. et al.,Organoapatites: Materials for Artificial Bone. II. Hardening Reactions and Properties,Journal of Biomedical Materials Research, vol. 27, 289-299, 1993.
Stupp, Samuel I. et al.,Organoapatites: Materials for Artificial Bone. III. Biological Testing, Journal of Biomedical Materials Research, vol. 27, pp. 301-311, 1993.
Wei, Guoxiong et al.,A Bioabsorable Delivery System for Antibiotic Treatment of Osteomyelitis,J. Bone Joint Surg.[Br], vol. 73-B, No. 2, pp. 246-252, 1991.
Cerrai, et al., “Block copolymers from L-lactide and poly(ethylene glycol) through a non-catalyzed route”,Makromol. Chem. Rapid Commun.,14, pp. 529-538 (1993).

Affiliated with

Also associated with

Rating

Bioerodable polymeric adhesives for tissue repair does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bioerodable polymeric adhesives for tissue repair, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioerodable polymeric adhesives for tissue repair will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3650482