Bioerodable implant composition comprising crosslinked biodegrad

Details Bioerodable implant composition comprising crosslinked biodegrad Bioerodable implant composition comprising crosslinked biodegrad

1989-05-12

1992-02-04

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

424423, 424602, 523116, 525 48, A61K 3174, A61K 608

Patent

active

050858610

ABSTRACT:
An improved bone cement is comprised of a particulate biocompatible calcium phosphate ceramic and particulate resorbable calcium salt dispersed in a cross-linked biodegradable polyester matrix. The polymer/salt-particle composite exhibits good biomechanical strength/modulus characteristics with surgically acceptable cure times. When used for sustained release of biologically active agents in a physiological environment, controlled release of biological agents that are mixed into the composite can be achieved as the cement biodegrades. When used for bone/implant fixation, or as a filler or cement for bone repair, gradual biodegradation of the cement composite permits, under suitable circumstances, evantual replacement of the cement with developing bone tissue.

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