Bioengineered tissue substitutes

Details Bioengineered tissue substitutes Bioengineered tissue substitutes

2003-02-24

2009-11-24

Ford, Allison M. (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Solid support and method of culturing cells on said solid...

C435S395000, C435S399000, C435S402000, C435S325000, C623S001100, C623S001150, C623S001220, C623S001270, C623S002100, C623S023690, C623S023700, C623S023720, C623S023760

Reexamination Certificate

active

07622299

ABSTRACT:
In one aspect, the invention provides methods for forming a target tissue substitute. The methods of the invention comprise the following steps: (a) providing a scaffold comprising one or more layers of one or more arrays of microfibers, wherein one or more of the arrays of microfibers is designed to mimic the configuration of one or more structural elements in a target tissue; and (b) culturing cells on the scaffold to form a target tissue substitute. In another aspect, the invention provides implantable medical devices. The implantable medical devices of the invention comprise a scaffold comprising one or more layers of one or more arrays of microfibers, wherein one or more of the arrays of microfibers is arranged to mimic the configuration of one or more structural elements in a target tissue. Typically, cells are cultured on the scaffold to form a target tissue substitute.

REFERENCES:
patent: 4878908 (1989-11-01), Martin et al.
patent: 5855610 (1999-01-01), Vacanti et al.
patent: 6106913 (2000-08-01), Scardino et al.
patent: 6308509 (2001-10-01), Scardino et al.
patent: 6348069 (2002-02-01), Vacanti et al.
patent: 6416995 (2002-07-01), Wolfinbarger
patent: 6432712 (2002-08-01), Wolfinbarger, Jr.
patent: 6455311 (2002-09-01), Vacanti
patent: 6503273 (2003-01-01), McAllister et al.
patent: 6537567 (2003-03-01), Niklason et al.
patent: 6592623 (2003-07-01), Bowlin et al.
patent: 2002/0188349 (2002-12-01), McAllister et al.
patent: 2003/0003153 (2003-01-01), Asculai et al.
Doi et al, “Novel compliant and tissue-permeable microporous polyurethane vascular prosthesis fabricated using an excimer laser ablation technique” Journal of Biomedical Material Research, 1996, vol. 31, pp. 27-33.
Hayashi, K., “Experimental Approaches on Measuring the Mechanical Properties and Constitutive Laws of Arterial Walls,”Journal of Biomechanical Engineering 115:481-488, Nov. 1993.
Sato, M., et al., “Axial Mechanical Properties of Arterial Walls and Their Anisotropy,”Medical&Biological Engineering&Computing 17(2):170-176, Mar. 1979.
Segurola, et al., “Letter to the Editor: Strain-Induced Dual Alignment of L6 Rat Skeletal Muscle Cells,”In Vitro Cellular&Developmental Biology 34:609-612, Jun. 1998.
Vandenburgh, H.H. et al., “Computer-Aided Mechanogenesis of Skeletal Muscle Organs From Single Cells In Vitro,”FASEB Journal 5(13):2860-2867, Oct. 1991.
Conklin, B.S., et al., “A Simple Physiologic Pulsatile Perfusion System for the Study of Intact Vascular Tissue,”Medical Engineering&Physics 22:441-449, 2000.
Doi, K., and T. Matsuda, “Significance of Porosity and Compliance of Microporous, Polyurethane-Based Microarterial Vessel on Neoarterial Wall Regeneration,”J. Biomed. Mater. Res. 37:573-584, 1997.
Doi, K., and T. Matsuda, “Enhanced Vascularization in a Microporous Polyurethane Graft Impregnated With Basic Fibroblast Growth Factor and Heparin,”J. Biomed. Mater. Res. 34:361-370, 1997.
Edelman, E.R., “Vascular Tissue Engineering: Designer Arteries,”Circulation Research 85:1115-1117, 1999.
Hoerstrup, S.P., et al., “A New Approach to Completely Autologous Cardiovascular Tissue in Humans,”ASAIO Journal 48:234-238, 2002.
Leor, J., et al., “Bioengineered Cardiac Grafts: A New Approach to Repair the Infarcted Myocardium?”Circulation 102[suppl III]:III-56-III-61, 2000.
L'Heureux, N., et al., “A Completely Biological Tissue-Engineered Human Blood Vessel,”FASEB Journal 12:47-56, 1998.
McVeigh, G.E., et al., “Evaluation of Mechanical Arterial Properties: Clinical, Experimental and Therapeutic Aspects,”Clinical Science 102:51-67, 2002.
Nerem, R.M., and D. Seliktar, “Vascular Tissue Engineering,”Annu. Rev. Biomed. Eng. 3:225-243, 2001.
Niklason, L.E., et al., “Functional Arteries Grown In Vitro,”Science 284:489-493, 1999.
Peng, X., et al., “In Vitro System to Study Realistic Pulsatile Flow and Stretch Signaling in Cultured Vascular Cells,”Am. J. Physiol. Cell Physiol. 279:C797-C805, 2000.
Powell, C.A., “Mechanical Stimulation Improves Tissue-Engineered Human Skeletal Muscle,”Am. J. Physiol. Cell Physiol. 283:C1557-C1565, 2002.
Ratcliffe, A., “Tissue Engineering of Vascular Grafts,”Matrix Biology 19:353-357, 2000.
Sanders, J.E., et al., “Tissue Response to Single-Polymer Fibers of Varying Diameters: Evaluation of Fibrous Encapsulation and Macrophage Density,”J. Biomed. Mater. Res. 52:231-237, 2000.
Sanders, J.E., et al., “Tissue Response to Microfibers of Different Polymers: Polyester, Polyethylene, Polylatic Acid, and Polyurethane,”J. Biomed. Mater. Res. 62(2):222-227, 2002.
Seifalian, A.M., et al., “Improving the Clinical Patency of Prosthetic Vascular and Coronary Bypass Grafts: The Role of Seeding and Tissue Engineering,”Artificial Organs 26(4):307-320, 2002.
Seliktar, D., “Dynamic Mechanical Conditioning of Collagen-Gel Blood Vessel Constructs Induces Remodeling In Vitro,”Annals of Biomedical Engineering 28:351-362, 2000.
Shum-Tim, D., et al., “Tissue Engineering of Autologous Aorta Using a New Biodegradable Polymer,”Ann. Thorac. Surg. 68:2298-2305, 1999.
Sieminski, A.L., and K.J. Gooch, “Biomaterial-Microvasculature Interactions,”Biomaterials 21:2233-2241, 2000.

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